Dextromethorphan modulates the AP-1 DNA-binding activity induced by kainic acid

Hyoung Chun Kim, Guoying Bing, Wang Kee Jhoo, Kwang Ho Ko, Won Ki Kim, Dong Chul Lee, Eun Jhoo Shin, Jau Shyong Hong

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


We have recently reported that dextromethorphan attenuates the neurotoxicity induced by kainic acid in a dose-related fashion. Pretreatments with dextromethorphan (50 mg/kg, p.o. X2) significantly reduced the activator protein-1 DNA-binding activity and the Fos-related antigen-immunoreactive protein induced by kainic acid (10 mg/kg, i.p.) in the CA1, but not the CA3 or the dentate gyms sector of the rat hippocampus. Paradoxically, dextromethorphan itself caused an elevated activator protein-1 DNA-binding activity and Fos-related antigen-immunoreactive protein in the CA1 region which lasted for at least 4 days. The results suggest that the CA1 area is the critical site for mediating the putative neuroprotective effect induced by dextromethorphan.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBrain Research
Issue number1
StatePublished - Apr 3 1999

Bibliographical note

Funding Information:
We would like to thank Dr. Jerome L. Maderdrut (Tulane University, New Orleans, LA) for his critical reading of this manuscript. This study was supported by the Korea Science and Engineering Foundation (KOSEF 981-0714-107-2).


  • Activator protein-1
  • Dextromethorphan
  • Fos-related antigen
  • Hippocampus
  • Kainic acid
  • Neuroprotection

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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