Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diabetes is poorly understood, and observations suggest that it is probably multifactorial. In this Review, we discuss the epidemiology, pathophysiology, and management considerations of diabetes following acute pancreatitis, and highlight knowledge gaps in this topic.
Bibliographical noteFunding Information:
Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK127388 (PAH, DB, DLC, KD, GIP), U01DK108327 (PAH, DB, DLC), U01DK126300 (MDB), U01DK127367 (MDB), U01DK108306 (DY), and U01DK127377 (DY). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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