Diabetes mellitus and prostate cancer risk among older men: Population-based case-control study

A. L. Coker; M. Sanderson; W. Zheng; M. K. Fadden

doi:10.1038/sj.bjc.6601857

Diabetes mellitus and prostate cancer risk among older men: Population-based case-control study

A. L. Coker
, M. Sanderson
, W. Zheng
, M. K. Fadden

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We investigate the relation between diabetes mellitus and risk of prostate cancer among older (age 65-79 years) men in a population-based case-control study of 407 incident histologically confirmed cases registered in the South Carolina Central Cancer Registry between 1999 and 2001 (70.6% response rate); controls were 393 men identified through the Health Care Financing Administration Medicare beneficiary file for South Carolina in 1999 (63.8% response rate). After adjusting for age, race, and prostate cancer screening in the past 5 years, a history of diabetes mellitus was associated with a reduced risk of prostate cancer (adjusted odds ratio (aOR) = 0.64; 95% confidence interval (CI) = 0.45, 0.91). The protective effect was stronger for those with complications associated with diabetes (aOR = 0.61; 95% CI = 0.42, 0.90) and for African-American men (aOR = 0.36; 95% CI = 0.21, 0.62). Additional research is needed to understand the biologic mechanisms by which diabetes may influence prostate cancer risk; genetic factors may play an important role in understanding this association.

Original language	English
Pages (from-to)	2171-2175
Number of pages	5
Journal	British Journal of Cancer
Volume	90
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6601857
State	Published - Jun 1 2004

Bibliographical note

Funding Information:
This research was supported by funding to Dr Maureen Sanderson from the Association of Schools of Public Health/Centres for Disease Control and Prevention and the National Cancer Institute.

Funding

This research was supported by funding to Dr Maureen Sanderson from the Association of Schools of Public Health/Centres for Disease Control and Prevention and the National Cancer Institute.

Funders
Association of Schools of Public Health/Centres for Disease Control and Prevention
National Childhood Cancer Registry – National Cancer Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

African-American
Diabetes mellitus
Epidemiologic studies
Prostate neoplasms

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/sj.bjc.6601857

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title = "Diabetes mellitus and prostate cancer risk among older men: Population-based case-control study",

abstract = "We investigate the relation between diabetes mellitus and risk of prostate cancer among older (age 65-79 years) men in a population-based case-control study of 407 incident histologically confirmed cases registered in the South Carolina Central Cancer Registry between 1999 and 2001 (70.6\% response rate); controls were 393 men identified through the Health Care Financing Administration Medicare beneficiary file for South Carolina in 1999 (63.8\% response rate). After adjusting for age, race, and prostate cancer screening in the past 5 years, a history of diabetes mellitus was associated with a reduced risk of prostate cancer (adjusted odds ratio (aOR) = 0.64; 95\% confidence interval (CI) = 0.45, 0.91). The protective effect was stronger for those with complications associated with diabetes (aOR = 0.61; 95\% CI = 0.42, 0.90) and for African-American men (aOR = 0.36; 95\% CI = 0.21, 0.62). Additional research is needed to understand the biologic mechanisms by which diabetes may influence prostate cancer risk; genetic factors may play an important role in understanding this association.",

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author = "Coker, \{A. L.\} and M. Sanderson and W. Zheng and Fadden, \{M. K.\}",

note = "Funding Information: This research was supported by funding to Dr Maureen Sanderson from the Association of Schools of Public Health/Centres for Disease Control and Prevention and the National Cancer Institute.",

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AU - Sanderson, M.

AU - Zheng, W.

AU - Fadden, M. K.

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Diabetes mellitus and prostate cancer risk among older men: Population-based case-control study

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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