Diabetes-related Amylin Dyshomeostasis: a Contributing Factor to Cerebrovascular Pathology and Dementia

Han Ly, Florin Despa

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Type 2 diabetes (T2D) increases the risk for cerebrovascular disease (CVD) and dementia. The underlying molecular mechanisms remain elusive, which hampers the development of treatment or/and effective prevention strategies. Recent studies suggest that dyshomeostasis of amylin, a satiety hormone that forms pancreatic amyloid in patients with T2D, promotes accumulation of amylin in cerebral small blood vessels and interaction with Alzheimer's disease (AD) pathology. Overexpression of human amylin in rodents (rodent amylin does not form amyloid) leads to late-life onset T2D and neurologic deficits. In this Review, we discuss clinical evidence of amylin pathology in CVD and AD and identify critical characteristics of animal models that could help to better understand molecular mechanisms underlying the increased risk of CVD and AD in patients with prediabetes or T2D.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalJournal of Lipid and Atherosclerosis
Issue number2
StatePublished - Sep 1 2019

Bibliographical note

Publisher Copyright:
© 2019 The Korean Society of Lipid and Atherosclerosis.


  • Alzheimer's disease
  • Amyloid
  • Cerebrovascular disease
  • Dementia
  • Diabetes complications
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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