Diagnosis of chronic pancreatitis incorporating endosonographic features, demographics, and behavioral risk

Linda S. Lee, Ying P. Tabak, Vivek Kadiyala, Xiaowu Sun, Shadeah Suleiman, Richard S. Johannes, Peter A. Banks, Darwin L. Conwell

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: Diagnosing chronic pancreatitis remains challenging. Endoscopic ultrasound (EUS) is utilized to evaluate pancreatic disease. Abnormal pancreas function test is considered the "nonhistologic" criterion standard for chronic pancreatitis.We derived a prediction model for abnormal endoscopic pancreatic function test (ePFT) by enriching EUS findings with patient demographic and pancreatitis behavioral risk characteristics. Methods: Demographics, behavioral risk characteristics, EUS findings, and peak bicarbonate results were collected from patients evaluated for pancreatic disease. Abnormal ePFTwas defined as peak bicarbonate of less than 75 mEq/L.We fit a logistic regression model and converted it to a risk score system. The risk score was validated using 1000 bootstrap simulations. Results: A total of 176 patientswere included; 61%were femalewithmedian age of 48 years (interquartile range, 38-57 years). Abnormal ePFT rate was 39.2% (69/176). Four variables formulated the risk score: alcohol or smoking status, number of parenchymal abnormalities, number of ductal abnormalities, and calcifications. Abnormal ePFT occurred in 10.7% with scores 4 or less versus 92.0% scoring 20 or greater. The model C-statistic was 0.78 (95% confidence interval, 0.71-0.85). Conclusions: Number of EUS pancreatic duct and parenchymal abnormalities, presence of calcification, and smoking/alcohol status were predictive of abnormal ePFT. This simple model has good discrimination for ePFT results.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
Issue number3
StatePublished - Mar 1 2017

Bibliographical note

Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.


  • Chronic pancreatitis
  • EUS
  • Endoscopic pancreatic function test
  • Pancreatic function test
  • Rosemont classification

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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