Diagnostic and Prognostic Laboratory Testing for Alzheimer Disease

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

This article focuses on current clinical laboratory testing to diagnose Alzheimer disease and monitor its progression throughout its disease course. Several clinically available tests focus on analysis of amyloid and tau levels in cerebrospinal fluid as well as autosomal dominant and risk factor genes. Although the current armament of clinical laboratory testing is limited by invasiveness of cerebrospinal fluid collection, rarity of autosomal dominant genetic mutations, and uncertainties of risk inherent in nonpenetrant genes, the field is poised to advance the clinical repertoire of laboratory diagnostic testing.

Original languageEnglish
Pages (from-to)289-303
Number of pages15
JournalClinics in Laboratory Medicine
Volume40
Issue number3
DOIs
StatePublished - Sep 2020

Bibliographical note

Funding Information:
Dr G.A. Jicha has provided contract research services for AbbVie. Alltech, Biohaven, Eisai, Janssen, Lilly, Novartis, and Suven. The other authors have nothing to disclose.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Alzheimer's disease
  • Cerebrospinal fluid (CSF)
  • Mild cognitive impairment (MCI)
  • Phospho-tau
  • Preclinical AD
  • Tau
  • β-amyloid (Aβ)

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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