TY - JOUR
T1 - Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues
T2 - Synthesis and preliminary evaluation
AU - Baranowska-Kortylewicz, Janina
AU - Pavlik, Edward J.
AU - Smith, Walter T.
AU - Flanigan, Robert C.
AU - Van Nagell, J. R.
AU - Ross, Dawn
AU - Kenady, Daniel E.
N1 - Funding Information:
Portions of this work were supported by the VeteransA dministration.
PY - 1985/10
Y1 - 1985/10
N2 - The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).
AB - The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).
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U2 - 10.1016/S0020-1693(00)81619-9
DO - 10.1016/S0020-1693(00)81619-9
M3 - Article
AN - SCOPUS:15944409350
SN - 0020-1693
VL - 108
SP - 91
EP - 98
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
IS - 2
ER -