Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation

Janina Baranowska-Kortylewicz, Edward J. Pavlik, Walter T. Smith, Robert C. Flanigan, J. R. Van Nagell, Dawn Ross, Daniel E. Kenady

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalInorganica Chimica Acta
Issue number2
StatePublished - Oct 1985

Bibliographical note

Funding Information:
Portions of this work were supported by the VeteransA dministration.

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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