Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation

Janina Baranowska-Kortylewicz; Edward J. Pavlik; Walter T. Smith; Robert C. Flanigan; J. R. Van Nagell; Dawn Ross; Daniel E. Kenady

doi:10.1016/S0020-1693(00)81619-9

Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation

Janina Baranowska-Kortylewicz, Edward J. Pavlik, Walter T. Smith, Robert C. Flanigan, J. R. Van Nagell, Dawn Ross, Daniel E. Kenady

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).

Original language	English
Pages (from-to)	91-98
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	108
Issue number	2
DOIs	https://doi.org/10.1016/S0020-1693(00)81619-9
State	Published - Oct 1985

Bibliographical note

Funding Information:
Portions of this work were supported by the VeteransA dministration.

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/S0020-1693(00)81619-9

Cite this

@article{002a2b6071b24efc858ee2572f9b98b0,

title = "Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation",

abstract = "The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).",

author = "Janina Baranowska-Kortylewicz and Pavlik, {Edward J.} and Smith, {Walter T.} and Flanigan, {Robert C.} and {Van Nagell}, {J. R.} and Dawn Ross and Kenady, {Daniel E.}",

note = "Funding Information: Portions of this work were supported by the VeteransA dministration.",

year = "1985",

month = oct,

doi = "10.1016/S0020-1693(00)81619-9",

language = "English",

volume = "108",

pages = "91--98",

number = "2",

}

TY - JOUR

T1 - Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues

T2 - Synthesis and preliminary evaluation

AU - Baranowska-Kortylewicz, Janina

AU - Pavlik, Edward J.

AU - Smith, Walter T.

AU - Flanigan, Robert C.

AU - Van Nagell, J. R.

AU - Ross, Dawn

AU - Kenady, Daniel E.

N1 - Funding Information: Portions of this work were supported by the VeteransA dministration.

PY - 1985/10

Y1 - 1985/10

N2 - The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).

AB - The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):∼20 × less; Pt(6-MHEAP): ∼100 × less).

UR - http://www.scopus.com/inward/record.url?scp=15944409350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15944409350&partnerID=8YFLogxK

U2 - 10.1016/S0020-1693(00)81619-9

DO - 10.1016/S0020-1693(00)81619-9

M3 - Article

AN - SCOPUS:15944409350

VL - 108

SP - 91

EP - 98

IS - 2

ER -

Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this