Dielectric modulation of biological water

Florin Despa, Ariel Fernández, R. Stephen Berry

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


A model which shows the librational dynamics undergone by water constrained by vicinal hydrophobes, which lowers the dielectric susceptibility and induces a 'redshift' of the relaxation frequency in the hydration shell was presented. The reduction of H-bond exchange possibilities of water molecules at a hydrophobic interface was analyzed. Water molecules were found to exchange H bonds with neighbours at a fast rate (Vb ≅1.7 × 10 13 s-1 at room temperature. The results also demonstrated the way in which proteins enhance their intramolecular interactions as they fold or associate.

Original languageEnglish
Article number228104
JournalPhysical Review Letters
Issue number22
StatePublished - Nov 29 2004

Bibliographical note

Funding Information:
We acknowledge the support of a grant from the National Science Foundation.

ASJC Scopus subject areas

  • General Physics and Astronomy


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