Dietary Antioxidant Insufficiency Is Associated with Increased Inflammatory Markers and Poorer Health-Related Quality of Life in Patients with Heart Failure

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Abstract

Background Antioxidant insufficiency, elevated inflammatory markers, and poor health-related quality of life (HRQOL) are prevalent in patients with heart failure (HF). Objective The objective of this study was to examine the associations among dietary antioxidant intake, inflammatory markers, and HRQOL in patients with HF. Methods This was a secondary analysis of 265 patients with HF who completed a 4-day food diary. We assessed intake of 10 antioxidants: alpha carotene, beta carotene, beta cryptoxanthin, lutein, zeaxanthin, lycopene, vitamins C and E, zinc, and selenium. Antioxidant insufficiency was reflected by a measured level for each antioxidant that was below the estimate average requirement or lower than median for antioxidants without an estimate average requirement. Inflammatory markers including serum C-reactive protein, cytokines (interleukins 6 and 10), tumor necrosis factor-alpha, and soluble receptors (sTNFR1 and sTNFR2) were assessed with enzyme immunoassay. Health-related quality of life was measured using the Minnesota Living with Heart Failure at 12 months. Results Dietary antioxidant insufficiency predicted C-reactive protein (β = 0.135, P =.032) and interleukin 10 (β = -.155, P =.027). Patients with higher antioxidant insufficiency had higher C-reactive protein and lower interleukin 10. Both antioxidant insufficiency (β = 0.13, P =.049) and higher C-reactive protein (β = 0.16, P =.019) were independently associated with poorer HRQOL while adjusting for covariates. Conclusions Dietary antioxidant insufficiency was associated with increased markers of inflammation and poorer HRQOL. Improvement of diet quality among patients with HF may be a fruitful area of research for enhancing HRQOL.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalJournal of Cardiovascular Nursing
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2023

Bibliographical note

Funding Information:
This study was supported by funding from the National Institute of Nursing Research of the National Institutes of Health under award number NR009280 (T. Lennie, PI) and the National Research Foundation of Korea (NRF) Grant by the Korean Government (NRF-2018R1D1A1A09083498) (E.K. Song, PI).

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • dietary antioxidant insufficiency
  • heart failure
  • inflammatory marker
  • nutrition
  • quality of life

ASJC Scopus subject areas

  • Medicine (all)

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