TY - JOUR
T1 - Dietary antioxidants in the prevention of hepatocarcinogenesis
T2 - A review
AU - Glauert, Howard P.
AU - Calfee-Mason, Karen
AU - Stemm, Divinia N.
AU - Tharappel, Job C.
AU - Spear, Brett T.
PY - 2010/7
Y1 - 2010/7
N2 - In this review, the role of dietary antioxidants in the prevention of hepatocarcinogenesis is examined. Both human and animal models are discussed. Vitamin C, vitamin E, and selenium are antioxidants that are essential in the human diet. A number of non-essential chemicals also contain antioxidant activity and are consumed in the human diet, mainly as plants or as supplements, including β-carotene, ellagic acid, curcumin, lycopene, coenzyme Q 10, epigallocatechin gallate, N-acetyl cysteine, and resveratrol. Although some human and animal studies show protection against carcinogenesis with the consumption of higher amounts of antioxidants, many studies show no effect or an enhancement ofcarcinogenesis. Because of the conflicting results from these studies, it is difficult to make dietary recommendations as to whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma.
AB - In this review, the role of dietary antioxidants in the prevention of hepatocarcinogenesis is examined. Both human and animal models are discussed. Vitamin C, vitamin E, and selenium are antioxidants that are essential in the human diet. A number of non-essential chemicals also contain antioxidant activity and are consumed in the human diet, mainly as plants or as supplements, including β-carotene, ellagic acid, curcumin, lycopene, coenzyme Q 10, epigallocatechin gallate, N-acetyl cysteine, and resveratrol. Although some human and animal studies show protection against carcinogenesis with the consumption of higher amounts of antioxidants, many studies show no effect or an enhancement ofcarcinogenesis. Because of the conflicting results from these studies, it is difficult to make dietary recommendations as to whether consuming higher amounts of specific antioxidants will decrease the risk of developing hepatocellular carcinoma.
KW - Liver
KW - Phytochemicals
KW - Selenium
KW - Vitamin C
KW - Vitamin E
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U2 - 10.1002/mnfr.200900482
DO - 10.1002/mnfr.200900482
M3 - Review article
C2 - 20512789
AN - SCOPUS:77954629491
SN - 1613-4125
VL - 54
SP - 875
EP - 896
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 7
ER -