Dietary fat intake and proinflammatory cytokine levels in patients with heart failure

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45 Scopus citations


Background: Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and soluble receptors sTNF-R1 and sTNF-R2 levels in patients with HF and (2) subsequent impact of these levels on event-free survival. Methods and Results: Forty-two patients provided 4-day food diaries and blood for cytokines. Event-free survival curves were calculated by Kaplan-Meier method and groups compared using log-rank test. IL-6 was not related to fat intake. TNF-α levels were elevated in patients with diets higher versus lower in saturated (6.9 ± 5 versus 4.2 ± 2 pg/mL) and trans fats (6.8 ± 4.5 versus 4.5 ± 2.8 pg/mL). Patients consuming diets higher in polyunsaturated fats had lower sTNF-R1 (2391 ± 1010 versus 3373 ± 2098 pg/mL) and sTNF-R2 (3803 ± 1187 versus 5974 ± 3275 pg/mL) levels. Higher omega-3 intake produced similar results: sTNF-R1 (2323 ± 1304 versus 3307 ± 1973) and sTNF-R2 (4117 ± 2646 versus 5409 ± 2801). Event-free survival was decreased in patients with higher TNF-α and sTNF-R1 levels. Conclusion: Dietary fat intake may affect proinflammatory cytokine levels in patients with HF. Research to determine whether changing composition of dietary fat can alter proinflammatory cytokine activity of HF patients is warranted.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalJournal of Cardiac Failure
Issue number8
StatePublished - Oct 2005

Bibliographical note

Funding Information:
Supported by the National American Heart Association Established Investigator Award to D. Moser; The Gill Endowment Fund to the University of Kentucky, College of Nursing; The Ohio State University College of Nursing; the University of Kentucky General Clinical Research Center (M01RR02602), and The Ohio State University General Clinical Research Center (M01RR00034).


  • Interleukin 6
  • Omega-3 fatty acids
  • Saturated fat
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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