Dietary fat intake and proinflammatory cytokine levels in patients with heart failure

Terry A. Lennie; Misook L. Chung; Diane L. Habash; Debra K. Moser

doi:10.1016/j.cardfail.2005.06.434

Dietary fat intake and proinflammatory cytokine levels in patients with heart failure

Terry A. Lennie, Misook L. Chung, Diane L. Habash, Debra K. Moser

College of Nursing

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Background: Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and soluble receptors sTNF-R1 and sTNF-R2 levels in patients with HF and (2) subsequent impact of these levels on event-free survival. Methods and Results: Forty-two patients provided 4-day food diaries and blood for cytokines. Event-free survival curves were calculated by Kaplan-Meier method and groups compared using log-rank test. IL-6 was not related to fat intake. TNF-α levels were elevated in patients with diets higher versus lower in saturated (6.9 ± 5 versus 4.2 ± 2 pg/mL) and trans fats (6.8 ± 4.5 versus 4.5 ± 2.8 pg/mL). Patients consuming diets higher in polyunsaturated fats had lower sTNF-R1 (2391 ± 1010 versus 3373 ± 2098 pg/mL) and sTNF-R2 (3803 ± 1187 versus 5974 ± 3275 pg/mL) levels. Higher omega-3 intake produced similar results: sTNF-R1 (2323 ± 1304 versus 3307 ± 1973) and sTNF-R2 (4117 ± 2646 versus 5409 ± 2801). Event-free survival was decreased in patients with higher TNF-α and sTNF-R1 levels. Conclusion: Dietary fat intake may affect proinflammatory cytokine levels in patients with HF. Research to determine whether changing composition of dietary fat can alter proinflammatory cytokine activity of HF patients is warranted.

Original language	English
Pages (from-to)	613-618
Number of pages	6
Journal	Journal of Cardiac Failure
Volume	11
Issue number	8
DOIs	https://doi.org/10.1016/j.cardfail.2005.06.434
State	Published - Oct 2005

Bibliographical note

Funding Information:
Supported by the National American Heart Association Established Investigator Award to D. Moser; The Gill Endowment Fund to the University of Kentucky, College of Nursing; The Ohio State University College of Nursing; the University of Kentucky General Clinical Research Center (M01RR02602), and The Ohio State University General Clinical Research Center (M01RR00034).

Keywords

Interleukin 6
Omega-3 fatty acids
Saturated fat
Tumor necrosis factor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cardfail.2005.06.434

Cite this

@article{d32896741e1b413897b100eb9a552938,

title = "Dietary fat intake and proinflammatory cytokine levels in patients with heart failure",

abstract = "Background: Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and soluble receptors sTNF-R1 and sTNF-R2 levels in patients with HF and (2) subsequent impact of these levels on event-free survival. Methods and Results: Forty-two patients provided 4-day food diaries and blood for cytokines. Event-free survival curves were calculated by Kaplan-Meier method and groups compared using log-rank test. IL-6 was not related to fat intake. TNF-α levels were elevated in patients with diets higher versus lower in saturated (6.9 ± 5 versus 4.2 ± 2 pg/mL) and trans fats (6.8 ± 4.5 versus 4.5 ± 2.8 pg/mL). Patients consuming diets higher in polyunsaturated fats had lower sTNF-R1 (2391 ± 1010 versus 3373 ± 2098 pg/mL) and sTNF-R2 (3803 ± 1187 versus 5974 ± 3275 pg/mL) levels. Higher omega-3 intake produced similar results: sTNF-R1 (2323 ± 1304 versus 3307 ± 1973) and sTNF-R2 (4117 ± 2646 versus 5409 ± 2801). Event-free survival was decreased in patients with higher TNF-α and sTNF-R1 levels. Conclusion: Dietary fat intake may affect proinflammatory cytokine levels in patients with HF. Research to determine whether changing composition of dietary fat can alter proinflammatory cytokine activity of HF patients is warranted.",

keywords = "Interleukin 6, Omega-3 fatty acids, Saturated fat, Tumor necrosis factor",

author = "Lennie, {Terry A.} and Chung, {Misook L.} and Habash, {Diane L.} and Moser, {Debra K.}",

note = "Funding Information: Supported by the National American Heart Association Established Investigator Award to D. Moser; The Gill Endowment Fund to the University of Kentucky, College of Nursing; The Ohio State University College of Nursing; the University of Kentucky General Clinical Research Center (M01RR02602), and The Ohio State University General Clinical Research Center (M01RR00034). ",

year = "2005",

month = oct,

doi = "10.1016/j.cardfail.2005.06.434",

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volume = "11",

pages = "613--618",

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T1 - Dietary fat intake and proinflammatory cytokine levels in patients with heart failure

AU - Lennie, Terry A.

AU - Chung, Misook L.

AU - Habash, Diane L.

AU - Moser, Debra K.

N1 - Funding Information: Supported by the National American Heart Association Established Investigator Award to D. Moser; The Gill Endowment Fund to the University of Kentucky, College of Nursing; The Ohio State University College of Nursing; the University of Kentucky General Clinical Research Center (M01RR02602), and The Ohio State University General Clinical Research Center (M01RR00034).

PY - 2005/10

Y1 - 2005/10

N2 - Background: Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and soluble receptors sTNF-R1 and sTNF-R2 levels in patients with HF and (2) subsequent impact of these levels on event-free survival. Methods and Results: Forty-two patients provided 4-day food diaries and blood for cytokines. Event-free survival curves were calculated by Kaplan-Meier method and groups compared using log-rank test. IL-6 was not related to fat intake. TNF-α levels were elevated in patients with diets higher versus lower in saturated (6.9 ± 5 versus 4.2 ± 2 pg/mL) and trans fats (6.8 ± 4.5 versus 4.5 ± 2.8 pg/mL). Patients consuming diets higher in polyunsaturated fats had lower sTNF-R1 (2391 ± 1010 versus 3373 ± 2098 pg/mL) and sTNF-R2 (3803 ± 1187 versus 5974 ± 3275 pg/mL) levels. Higher omega-3 intake produced similar results: sTNF-R1 (2323 ± 1304 versus 3307 ± 1973) and sTNF-R2 (4117 ± 2646 versus 5409 ± 2801). Event-free survival was decreased in patients with higher TNF-α and sTNF-R1 levels. Conclusion: Dietary fat intake may affect proinflammatory cytokine levels in patients with HF. Research to determine whether changing composition of dietary fat can alter proinflammatory cytokine activity of HF patients is warranted.

AB - Background: Dietary fat intake affects proinflammatory cytokine levels of healthy adults. Whether dietary fats have similar effects in patients with heart failure (HF) is unknown. The purposes of this study were to determine (1) effect of dietary fat on interleukin (IL)-6, tumor necrosis factor (TNF)-α, and soluble receptors sTNF-R1 and sTNF-R2 levels in patients with HF and (2) subsequent impact of these levels on event-free survival. Methods and Results: Forty-two patients provided 4-day food diaries and blood for cytokines. Event-free survival curves were calculated by Kaplan-Meier method and groups compared using log-rank test. IL-6 was not related to fat intake. TNF-α levels were elevated in patients with diets higher versus lower in saturated (6.9 ± 5 versus 4.2 ± 2 pg/mL) and trans fats (6.8 ± 4.5 versus 4.5 ± 2.8 pg/mL). Patients consuming diets higher in polyunsaturated fats had lower sTNF-R1 (2391 ± 1010 versus 3373 ± 2098 pg/mL) and sTNF-R2 (3803 ± 1187 versus 5974 ± 3275 pg/mL) levels. Higher omega-3 intake produced similar results: sTNF-R1 (2323 ± 1304 versus 3307 ± 1973) and sTNF-R2 (4117 ± 2646 versus 5409 ± 2801). Event-free survival was decreased in patients with higher TNF-α and sTNF-R1 levels. Conclusion: Dietary fat intake may affect proinflammatory cytokine levels in patients with HF. Research to determine whether changing composition of dietary fat can alter proinflammatory cytokine activity of HF patients is warranted.

KW - Interleukin 6

KW - Omega-3 fatty acids

KW - Saturated fat

KW - Tumor necrosis factor

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SN - 1071-9164

VL - 11

SP - 613

EP - 618

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

IS - 8

ER -

Dietary fat intake and proinflammatory cytokine levels in patients with heart failure

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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