Dietary flavonoids as cancer prevention agents

Hua Yao, Weizheng Xu, Xianglin Shi, Zhuo Zhang

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.

Original languageEnglish
Pages (from-to)1-31
Number of pages31
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume29
Issue number1
DOIs
StatePublished - Jan 2011

Bibliographical note

Funding Information:
This work was supported by the International Science and Technology Cooperation Program of Zhejiang Province, China (grant no. 2010C34008) by Zhejiang Provincial Natural Science Foundation of China (Grant No. Y2100343), and by US National Institutes of Health (grant no. R01ES015375-02).

Keywords

  • EGCG
  • Naturally occurring cancer prevention agents
  • angiogenesis
  • antioxidant
  • apoptosis
  • cell cycle arrest
  • curcumin
  • dietary flavonoids
  • isothiocyanates
  • mechanistic insight
  • molecular targeting approach
  • oxidative stress
  • signal transduction pathways

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Cancer Research

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