Abstract
Dietary agents identified from fruits and vegetables contribute to keeping balanced cell proliferation and preventing cell carcinogenesis. Dietary flavonoids, combined with other components such as various vitamins, play an important role in cancer prevention. Flavonoids act on reactive oxygen species, cell signal transduction pathways related to cellular proliferation, apoptosis, and angiogenesis. Many studies demonstrate that flavonoids are responsible for chemoprevention, although mechanisms of action remain to be investigated. Overall, exciting data show that dietary flavonoids could be considered as a useful cancer preventive approach. This review summarizes recent advancements on potential cancer preventive effects and mechanic insight of dietary flavonoids.
Original language | English |
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Pages (from-to) | 1-31 |
Number of pages | 31 |
Journal | Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2011 |
Bibliographical note
Funding Information:This work was supported by the International Science and Technology Cooperation Program of Zhejiang Province, China (grant no. 2010C34008) by Zhejiang Provincial Natural Science Foundation of China (Grant No. Y2100343), and by US National Institutes of Health (grant no. R01ES015375-02).
Keywords
- EGCG
- Naturally occurring cancer prevention agents
- angiogenesis
- antioxidant
- apoptosis
- cell cycle arrest
- curcumin
- dietary flavonoids
- isothiocyanates
- mechanistic insight
- molecular targeting approach
- oxidative stress
- signal transduction pathways
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Cancer Research