Background: Vitamin C deficiency is prevalent in adults with heart failure (HF). Little is known about the relationship of dietary Vitamin C deficiency with health outcomes in adults with HF. Objective: The study's aim was to determine the relationships of Vitamin C deficiency measured at baseline with health-related quality of life (HRQOL) and cardiac event-free survival in patients with HF measured 1 year later. Method: A total of 251 patients with HF completed a 4-day food diary. Dietary Vitamin C deficiency was defined as daily intake less than the estimated average requirement from the Institute of Medicine of 75 mg/d for men and 60 mg/d for women. Health-related quality of life was assessed using the Minnesota Living with Heart Failure Questionnaire at 12 months. Patients were followed for a median of 1 year to determine time to the first event of cardiac-related hospitalization or death. Data were analyzed by hierarchical linear and Cox proportional hazards regressions. Results: One hundred patients (40%) had Vitamin C deficiency. Dietary Vitamin C deficiency was associated with poorer HRQOL at 12 months (β = 0.16, P =.02) after controlling for demographic and clinical variables. During the follow-up period, 59 patients (24%) had cardiac events. In Cox regression, Vitamin C deficiency predicted shorter cardiac event-free survival after adjusting for the same covariates (hazards ratio, 1.95; 95% confidence interval, 1.08-3.51). Conclusion: Vitamin C deficiency was associated with poorer HRQOL and shorter cardiac event-free survival in patients with HF. The findings suggest that encouraging patients with HF to consume a diet rich in fruits/vegetables to prevent Vitamin C deficiency may lead to better health outcomes.
|Number of pages
|Journal of Cardiovascular Nursing
|Published - Jan 1 2019
Bibliographical noteFunding Information:
This study was supported by funding from the National Institute of Nursing Research of the National Institutes of Health under award number NR009280 (T.A.L., PI) and the National Research Foundation of Korea (NRF) Grant by the Korean Government (NRF-2015R1D1A1A01059392) (E.K.S., PI). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Nursing Research or the National Institutes of Health.
© 2018 Lippincott Williams and Wilkins. All rights reserved.
- cardiac event-free survival
- dietary Vitamin C deficiency
- heart failure
- quality of life
ASJC Scopus subject areas
- Medicine (all)