TY - JOUR
T1 - Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats
AU - Glauert, Howard P.
AU - Lu, Zijing
AU - Kumar, Amita
AU - Bunaciu, R. Petruta
AU - Patel, Sandip
AU - Tharappel, Job C.
AU - Stemm, Divinia N.
AU - Lehmler, Hans Joachim
AU - Lee, Eun Y.
AU - Robertson, Larry W.
AU - Spear, Brett T.
PY - 2005/2
Y1 - 2005/2
N2 - In this study, the effect of dietary vitamin E on the hepatic tumor-promoting activity of PCB-77 and PCB-153 in female Sprague-Dawley rats (175-200 g) was investigated. One week after diethylnitrosamine injection, rats were fed purified diets containing 10, 50, or 250 mg/kg vitamin E in the form of α-tocopheryl acetate. Starting 1 wk later, we injected rats i.p. with vehicle (corn oil) or PCB-77 or PCB-153 (300 μmol/kg) every 14 d for 4 injections. All rats were killed 10 d after the last PCB injection. The number and volume of placental glutathione S-transferase (PGST)-positive foci were increased by PCB-77 but not by PCB-153. Vitamin E did not affect the induction of PGST-positive foci. PCB-77, but not PCB-153, increased hepatic NF-κB activity. In conclusion, dietary vitamin E supplementation does not protect against the induction of altered hepatic focal lesions by PCBs.
AB - In this study, the effect of dietary vitamin E on the hepatic tumor-promoting activity of PCB-77 and PCB-153 in female Sprague-Dawley rats (175-200 g) was investigated. One week after diethylnitrosamine injection, rats were fed purified diets containing 10, 50, or 250 mg/kg vitamin E in the form of α-tocopheryl acetate. Starting 1 wk later, we injected rats i.p. with vehicle (corn oil) or PCB-77 or PCB-153 (300 μmol/kg) every 14 d for 4 injections. All rats were killed 10 d after the last PCB injection. The number and volume of placental glutathione S-transferase (PGST)-positive foci were increased by PCB-77 but not by PCB-153. Vitamin E did not affect the induction of PGST-positive foci. PCB-77, but not PCB-153, increased hepatic NF-κB activity. In conclusion, dietary vitamin E supplementation does not protect against the induction of altered hepatic focal lesions by PCBs.
KW - Altered hepatic foci
KW - NF-κB
KW - Polychlorinated biphenyls
KW - Vitamin E
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U2 - 10.1093/jn/135.2.283
DO - 10.1093/jn/135.2.283
M3 - Article
C2 - 15671227
AN - SCOPUS:19944434160
SN - 0022-3166
VL - 135
SP - 283
EP - 286
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 2
ER -