Different lymphocyte activity in patients with polycythaemia vera versus secondary polycythaemia and healthy blood donors

Félix Rueda, A. Remacha, F. Marti, G. Piñol, J. Soler, C. Guañabens, E. Gimferrer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

On comparing lymphocyte patterns in patients with polycythaemia vera (PV) versus healthy blood donors (NC) and patients with secondary polycythaemia (SP), we observed an altered CD4/CD8 ratio (p <0.01) mainly due to the decreased CD8 subpopulation in PV. We found an increased lymphocyte activity in PV patients when compared with both SP and NC: the interleukin 2 (IL-2) production was significantly higher (p <0.001) as was the lymphoproliferative response both to phytohaemagglutinin (p <0.001) and IL-2 (p < 0.005). No significant differences were found between NC and SP. None of the PHA-stimulated PBMC samples from PV, SP or NC produced erythropoietin (EPO)-like or EPO-inhibitory activity. Our findings suggest an altered lymphoid lineage in PV patients.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalActa Haematologica
Volume83
Issue number1
DOIs
StatePublished - 1990

Keywords

  • Interleukin 2
  • Lymphocytes
  • Polycythaemia

ASJC Scopus subject areas

  • Hematology

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