Abstract
Divided into basal, midventricular, and apical regions. Additionally, the midventricular myocardium was divided into three transmural layers with each layer partitioned into four segments (i.e., septal, inferior, lateral, and anterior). Peak systolic strains and torsion were quantified for each region. Isoproterenol significantly increased peak systolic radial strain and circumferentiallongitudinal (CL) shear strain, as well as ventricular torsion, throughout the basal, midventricle, and apical regions. In the midventricle, isoproterenol significantly increased peak systolic radial strain, and induced significant increases in peak systolic circumferential strain and longitudinal strain in the septum. Isoproterenol consistently increased peak systolic CL shear strain in all midventricular segments. Ventricular torsion was significantly increased in nearly all segments except the inferior subendocardium. The effects of isoproterenol on LV systolic mechanics (i.e., threedimensional (3D) strains and torsion) in healthy rats depend on the region. This region dependency is also strain component-specific. These results provide insight into the regional response of LV mechanics to β-adrenergic stimulation in rats and could act as a baseline for future studies on subclinical abnormalities associated with the inotropic response in heart disease.
Original language | English |
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Article number | 060904 |
Journal | Journal of Biomechanical Engineering |
Volume | 141 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2019 |
Bibliographical note
Publisher Copyright:© 2019 by ASME.
Funding
Funders | Funder number |
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National Heart, Lung, and Blood Institute (NHLBI) | U01HL133359 |
ASJC Scopus subject areas
- Biomedical Engineering
- Physiology (medical)