Differential expression levels of Par-4 in melanoma

T. Lucas, B. Pratscher, S. Krishnan, D. Fink, P. Günsberg, M. Wolschek, V. Wacheck, T. Muster, I. Romirer, K. Wolff, H. Pehamberger, H. G. Eichler, V. M. Rangnekar, B. Jansen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The pro-apoptotic prostate apoptosis response-4 gene product Par-4 sensitizes prostate cells to the induction of programmed cell death. In this study we examined Par-4 expression in human melanoma cell lines and melanoma metastases. The heterogeneous expression detected prompted us to investigate the biological relevance of Par-4 in a human melanoma xenotransplantation model. Overexpression of Par-4 by transfection decreased tumour development in xenotransplanted A375-C6 melanoma cells in SCID mice and correlated to an increase in tumour cell apoptosis. These data suggest that high expression of the pro-apoptotic protein Par-4 could qualify as a prognostic marker in human melanoma.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalMelanoma Research
Issue number4
StatePublished - 2001


  • Apoptosis
  • Melanoma
  • Par-4
  • Tumour
  • Xenotransplantation

ASJC Scopus subject areas

  • Oncology
  • Dermatology
  • Cancer Research


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