Differential expression levels of Par-4 in melanoma

T. Lucas; B. Pratscher; S. Krishnan; D. Fink; P. Günsberg; M. Wolschek; V. Wacheck; T. Muster; I. Romirer; K. Wolff; H. Pehamberger; H. G. Eichler; V. M. Rangnekar; B. Jansen

doi:10.1097/00008390-200108000-00008

Differential expression levels of Par-4 in melanoma

T. Lucas, B. Pratscher, S. Krishnan, D. Fink, P. Günsberg, M. Wolschek, V. Wacheck, T. Muster, I. Romirer, K. Wolff, H. Pehamberger, H. G. Eichler, V. M. Rangnekar, B. Jansen

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The pro-apoptotic prostate apoptosis response-4 gene product Par-4 sensitizes prostate cells to the induction of programmed cell death. In this study we examined Par-4 expression in human melanoma cell lines and melanoma metastases. The heterogeneous expression detected prompted us to investigate the biological relevance of Par-4 in a human melanoma xenotransplantation model. Overexpression of Par-4 by transfection decreased tumour development in xenotransplanted A375-C6 melanoma cells in SCID mice and correlated to an increase in tumour cell apoptosis. These data suggest that high expression of the pro-apoptotic protein Par-4 could qualify as a prognostic marker in human melanoma.

Original language	English
Pages (from-to)	379-383
Number of pages	5
Journal	Melanoma Research
Volume	11
Issue number	4
DOIs	https://doi.org/10.1097/00008390-200108000-00008
State	Published - 2001

Keywords

Apoptosis
Melanoma
Par-4
Tumour
Xenotransplantation

ASJC Scopus subject areas

Oncology
Dermatology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00008390-200108000-00008

Cite this

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title = "Differential expression levels of Par-4 in melanoma",

abstract = "The pro-apoptotic prostate apoptosis response-4 gene product Par-4 sensitizes prostate cells to the induction of programmed cell death. In this study we examined Par-4 expression in human melanoma cell lines and melanoma metastases. The heterogeneous expression detected prompted us to investigate the biological relevance of Par-4 in a human melanoma xenotransplantation model. Overexpression of Par-4 by transfection decreased tumour development in xenotransplanted A375-C6 melanoma cells in SCID mice and correlated to an increase in tumour cell apoptosis. These data suggest that high expression of the pro-apoptotic protein Par-4 could qualify as a prognostic marker in human melanoma.",

keywords = "Apoptosis, Melanoma, Par-4, Tumour, Xenotransplantation",

author = "T. Lucas and B. Pratscher and S. Krishnan and D. Fink and P. G{\"u}nsberg and M. Wolschek and V. Wacheck and T. Muster and I. Romirer and K. Wolff and H. Pehamberger and Eichler, {H. G.} and Rangnekar, {V. M.} and B. Jansen",

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language = "English",

volume = "11",

pages = "379--383",

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T1 - Differential expression levels of Par-4 in melanoma

AU - Lucas, T.

AU - Pratscher, B.

AU - Krishnan, S.

AU - Fink, D.

AU - Günsberg, P.

AU - Wolschek, M.

AU - Wacheck, V.

AU - Muster, T.

AU - Romirer, I.

AU - Wolff, K.

AU - Pehamberger, H.

AU - Eichler, H. G.

AU - Rangnekar, V. M.

AU - Jansen, B.

PY - 2001

Y1 - 2001

N2 - The pro-apoptotic prostate apoptosis response-4 gene product Par-4 sensitizes prostate cells to the induction of programmed cell death. In this study we examined Par-4 expression in human melanoma cell lines and melanoma metastases. The heterogeneous expression detected prompted us to investigate the biological relevance of Par-4 in a human melanoma xenotransplantation model. Overexpression of Par-4 by transfection decreased tumour development in xenotransplanted A375-C6 melanoma cells in SCID mice and correlated to an increase in tumour cell apoptosis. These data suggest that high expression of the pro-apoptotic protein Par-4 could qualify as a prognostic marker in human melanoma.

AB - The pro-apoptotic prostate apoptosis response-4 gene product Par-4 sensitizes prostate cells to the induction of programmed cell death. In this study we examined Par-4 expression in human melanoma cell lines and melanoma metastases. The heterogeneous expression detected prompted us to investigate the biological relevance of Par-4 in a human melanoma xenotransplantation model. Overexpression of Par-4 by transfection decreased tumour development in xenotransplanted A375-C6 melanoma cells in SCID mice and correlated to an increase in tumour cell apoptosis. These data suggest that high expression of the pro-apoptotic protein Par-4 could qualify as a prognostic marker in human melanoma.

KW - Apoptosis

KW - Melanoma

KW - Par-4

KW - Tumour

KW - Xenotransplantation

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UR - http://www.scopus.com/inward/citedby.url?scp=0034901756&partnerID=8YFLogxK

U2 - 10.1097/00008390-200108000-00008

DO - 10.1097/00008390-200108000-00008

M3 - Article

C2 - 11479426

AN - SCOPUS:0034901756

SN - 0960-8931

VL - 11

SP - 379

EP - 383

JO - Melanoma Research

JF - Melanoma Research

IS - 4

ER -

Differential expression levels of Par-4 in melanoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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