Differential facilitation of high- and low-output nerve terminals from a single motoneuron

Misty E. Crider, Robin L. Cooper

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


In the crayfish opener neuromuscular preparation, regional differences in synaptic transmission are observed among the terminals of a single motoneuron. With a single stimulus, the high-output terminals of the proximal region of the muscle produce a larger excitatory postsynaptic potential than do the low-output terminals of the central region of the muscle. We tested the hypothesis that the low-output terminals exhibit more facilitation than do high-output terminals for twinpulse, train, and continuous-stimulation paradigms. Previous studies have not employed several stimulation paradigms to induce facilitation among high- and low-output terminals of a single motoneuron. We found that the high-output terminals on the proximal fibers facilitate more than the low-output terminals on the central muscle fibers, in contrast with previous studies on similar muscles. The difference in measured facilitation is dependent on the stimulation paradigm. These results are important because ultrastructural differences between these high- and low-output terminals are known and can be used for correlation with physiological measurements. Short-term facilitation is a form of short-term memory at the synaptic level, and the processes understood at the crayfish neuromuscular junction may well be applicable to all chemical synapses.

Original languageEnglish
Pages (from-to)987-996
Number of pages10
JournalJournal of Applied Physiology
Issue number3
StatePublished - Mar 2000


  • Crayfish
  • Neuromuscular junction
  • Synapse

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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