Abstract
c-Jun NH2-terminal kinase (JNK) 1 and JNK2 have been assumed to complement each other and mediate the same or similar biological functions. However, our recent reports indicated that 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced tumor development is suppressed in Jnk2 knockout mice but enhanced in Jnk1 knockout mice. In the present work, primary embryo cells were isolated from wild-type, Jnk1-/- and Jnk2-/- mice and used for cDNA microarray analysis. The patterns of gene expression in Jnk1-/-, Jnk2-/-, and wild-type cells are different. After 12-O-tetradecanoylphorbol-13-acetate treatment, the changes in the gene expression profiles in three different kinds of cells appear to agree with the differences in susceptibility to tumori-genesis of each respective animal model. These results suggest that JNK1 and JNK2 proteins have different roles in modulating cell function.
Original language | English |
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Pages (from-to) | 1300-1304 |
Number of pages | 5 |
Journal | Cancer Research |
Volume | 62 |
Issue number | 5 |
State | Published - Mar 1 2002 |
Bibliographical note
Copyright:Copyright 2008 Elsevier B.V., All rights reserved.
ASJC Scopus subject areas
- Oncology
- Cancer Research