Abstract
Large bilateral aspiration lesions of the hippocampus in rats lead to a variety of changes in spontaneous behavior measured in an open field/hole board, relative to sham and neocortically lesioned controls. These changes include increased locomotion, and decreased grooming frequency and rearing bout duration. When animals were injected with the dopamine (DA) agonist 3,4-dihydroxyphenylamino-2-imidazoline (DPI: 0.5, 1.0 and 5.0 μg) into the nucleus accumbens one week after surgery, the behavior of hippocampally lesioned rats was restored to levels not different from control lesioned rats. Haloperidol injections (0.05, 0.1 and 0.5 μg) into the caudate nucleus were not able to do this. Further, DPI injected into the caudate nucleus one month after surgery was also able to attenuate some of the effects of hippocampal damage. On the other hand, haloperidol injections into the nucleus accumbens did not influence behavior. The results are interpreted in terms of hippocampal lesion-induced alteration of a balance in basal ganglia DA systems, indicated by modified response to pharmacological intervention and which mediate the behavioral effects of the lesion.
Original language | English |
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Pages (from-to) | 83-91 |
Number of pages | 9 |
Journal | Brain Research |
Volume | 291 |
Issue number | 1 |
DOIs | |
State | Published - Jan 16 1984 |
Keywords
- caudate nucleus
- dopamine
- hippocampal lesions
- nucleus accumbens
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology