Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type

Brian T. Gold; Dave A. Balota; Michael J. Cortese; Susan D. Sergent-Marshall; Abraham Z. Snyder; David H. Salat; Bruce Fischl; Anders M. Dale; John C. Morris; Randy L. Buckner

doi:10.1016/j.neuropsychologia.2004.10.005

Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type

Brian T. Gold, Dave A. Balota, Michael J. Cortese, Susan D. Sergent-Marshall, Abraham Z. Snyder, David H. Salat, Bruce Fischl, Anders M. Dale, John C. Morris, Randy L. Buckner

Neuroscience

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Individuals with semantic dementia (SD) were differentiated neuropsychologically from individuals with dementia of the Alzheimer type (DAT) at very mild-to-mild stages (clinical dementia rating 0.5 or 1). A picture naming and recognition memory experiment provided a particularly useful probe for early identification, with SD individuals showing preserved picture recognition memory and impaired naming, and DAT individuals tending to show the reverse dissociation. The identification of an early SD group provided the opportunity to inform models of reading by exploring the influence of isolated lexical semantic impairment on reading regular words. Results demonstrated prolonged latency in both SD and DAT group reading compared to a control group but exaggerated influence of frequency and length only for the SD group. The SD reading pattern was associated with focal atrophy of the left temporal pole. These cognitive-neuroanatomical findings suggest a role for the left temporal pole in lexical/semantic components of reading and demonstrate that cortical thickness differences in the left temporal pole correlate with prolonged latency associated with increased reliance on sublexical components of reading.

Original language	English
Pages (from-to)	833-846
Number of pages	14
Journal	Neuropsychologia
Volume	43
Issue number	6
DOIs	https://doi.org/10.1016/j.neuropsychologia.2004.10.005
State	Published - 2005

Bibliographical note

Funding Information:
We thank the control subjects and the patients and their caregivers for volunteering their time for this research project. We also thank clinicians at ADRC for helping to identify patients, Drs. Andrew Kertesz, Martha Storandt, Jon Simons, Max Coltheart, and two anonymous reviewers for helpful discussion and Dr. Matt Lambon Ralph for allowing us to use several tests. Finally, we thank Laura Williams, Daniella Van Hooren, and Jeff Templeton for help with data collection. The research was supported in part by NIA (AG05681, AG03991), NIMH (MH57506), the Alzheimer's Association (IIRG-00-1944), the James S McDonnell Foundation and the Howard Hughes Medical Institute. Additional support was provided by the National Center for Research Resources (P41-RR14075 and R01-RR13609), the Mental Illness and Neuroscience Discovery (MIND) Institute and the Biomedical Informatics Research Network Project (BIRN, http://www.nbirn.net ), which is funded by the National Center for Research Resources at the National Institutes of Health (NCRR BIRN Morphometric Project BIRN002).

Keywords

Alzheimer's
Frontotemporal dementia
Reading
Recognition memory
Semantic dementia

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neuropsychologia.2004.10.005

Cite this

Gold, B. T., Balota, D. A., Cortese, M. J., Sergent-Marshall, S. D., Snyder, A. Z., Salat, D. H., Fischl, B., Dale, A. M., Morris, J. C., & Buckner, R. L. (2005). Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type. Neuropsychologia, 43(6), 833-846. https://doi.org/10.1016/j.neuropsychologia.2004.10.005

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title = "Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type",

abstract = "Individuals with semantic dementia (SD) were differentiated neuropsychologically from individuals with dementia of the Alzheimer type (DAT) at very mild-to-mild stages (clinical dementia rating 0.5 or 1). A picture naming and recognition memory experiment provided a particularly useful probe for early identification, with SD individuals showing preserved picture recognition memory and impaired naming, and DAT individuals tending to show the reverse dissociation. The identification of an early SD group provided the opportunity to inform models of reading by exploring the influence of isolated lexical semantic impairment on reading regular words. Results demonstrated prolonged latency in both SD and DAT group reading compared to a control group but exaggerated influence of frequency and length only for the SD group. The SD reading pattern was associated with focal atrophy of the left temporal pole. These cognitive-neuroanatomical findings suggest a role for the left temporal pole in lexical/semantic components of reading and demonstrate that cortical thickness differences in the left temporal pole correlate with prolonged latency associated with increased reliance on sublexical components of reading.",

keywords = "Alzheimer's, Frontotemporal dementia, Reading, Recognition memory, Semantic dementia",

author = "Gold, {Brian T.} and Balota, {Dave A.} and Cortese, {Michael J.} and Sergent-Marshall, {Susan D.} and Snyder, {Abraham Z.} and Salat, {David H.} and Bruce Fischl and Dale, {Anders M.} and Morris, {John C.} and Buckner, {Randy L.}",

note = "Funding Information: We thank the control subjects and the patients and their caregivers for volunteering their time for this research project. We also thank clinicians at ADRC for helping to identify patients, Drs. Andrew Kertesz, Martha Storandt, Jon Simons, Max Coltheart, and two anonymous reviewers for helpful discussion and Dr. Matt Lambon Ralph for allowing us to use several tests. Finally, we thank Laura Williams, Daniella Van Hooren, and Jeff Templeton for help with data collection. The research was supported in part by NIA (AG05681, AG03991), NIMH (MH57506), the Alzheimer's Association (IIRG-00-1944), the James S McDonnell Foundation and the Howard Hughes Medical Institute. Additional support was provided by the National Center for Research Resources (P41-RR14075 and R01-RR13609), the Mental Illness and Neuroscience Discovery (MIND) Institute and the Biomedical Informatics Research Network Project (BIRN, http://www.nbirn.net ), which is funded by the National Center for Research Resources at the National Institutes of Health (NCRR BIRN Morphometric Project BIRN002). ",

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Gold, BT, Balota, DA, Cortese, MJ, Sergent-Marshall, SD, Snyder, AZ, Salat, DH, Fischl, B, Dale, AM, Morris, JC & Buckner, RL 2005, 'Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type', Neuropsychologia, vol. 43, no. 6, pp. 833-846. https://doi.org/10.1016/j.neuropsychologia.2004.10.005

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T1 - Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type

AU - Gold, Brian T.

AU - Balota, Dave A.

AU - Cortese, Michael J.

AU - Sergent-Marshall, Susan D.

AU - Snyder, Abraham Z.

AU - Salat, David H.

AU - Fischl, Bruce

AU - Dale, Anders M.

AU - Morris, John C.

AU - Buckner, Randy L.

N1 - Funding Information: We thank the control subjects and the patients and their caregivers for volunteering their time for this research project. We also thank clinicians at ADRC for helping to identify patients, Drs. Andrew Kertesz, Martha Storandt, Jon Simons, Max Coltheart, and two anonymous reviewers for helpful discussion and Dr. Matt Lambon Ralph for allowing us to use several tests. Finally, we thank Laura Williams, Daniella Van Hooren, and Jeff Templeton for help with data collection. The research was supported in part by NIA (AG05681, AG03991), NIMH (MH57506), the Alzheimer's Association (IIRG-00-1944), the James S McDonnell Foundation and the Howard Hughes Medical Institute. Additional support was provided by the National Center for Research Resources (P41-RR14075 and R01-RR13609), the Mental Illness and Neuroscience Discovery (MIND) Institute and the Biomedical Informatics Research Network Project (BIRN, http://www.nbirn.net ), which is funded by the National Center for Research Resources at the National Institutes of Health (NCRR BIRN Morphometric Project BIRN002).

PY - 2005

Y1 - 2005

N2 - Individuals with semantic dementia (SD) were differentiated neuropsychologically from individuals with dementia of the Alzheimer type (DAT) at very mild-to-mild stages (clinical dementia rating 0.5 or 1). A picture naming and recognition memory experiment provided a particularly useful probe for early identification, with SD individuals showing preserved picture recognition memory and impaired naming, and DAT individuals tending to show the reverse dissociation. The identification of an early SD group provided the opportunity to inform models of reading by exploring the influence of isolated lexical semantic impairment on reading regular words. Results demonstrated prolonged latency in both SD and DAT group reading compared to a control group but exaggerated influence of frequency and length only for the SD group. The SD reading pattern was associated with focal atrophy of the left temporal pole. These cognitive-neuroanatomical findings suggest a role for the left temporal pole in lexical/semantic components of reading and demonstrate that cortical thickness differences in the left temporal pole correlate with prolonged latency associated with increased reliance on sublexical components of reading.

AB - Individuals with semantic dementia (SD) were differentiated neuropsychologically from individuals with dementia of the Alzheimer type (DAT) at very mild-to-mild stages (clinical dementia rating 0.5 or 1). A picture naming and recognition memory experiment provided a particularly useful probe for early identification, with SD individuals showing preserved picture recognition memory and impaired naming, and DAT individuals tending to show the reverse dissociation. The identification of an early SD group provided the opportunity to inform models of reading by exploring the influence of isolated lexical semantic impairment on reading regular words. Results demonstrated prolonged latency in both SD and DAT group reading compared to a control group but exaggerated influence of frequency and length only for the SD group. The SD reading pattern was associated with focal atrophy of the left temporal pole. These cognitive-neuroanatomical findings suggest a role for the left temporal pole in lexical/semantic components of reading and demonstrate that cortical thickness differences in the left temporal pole correlate with prolonged latency associated with increased reliance on sublexical components of reading.

KW - Alzheimer's

KW - Frontotemporal dementia

KW - Reading

KW - Recognition memory

KW - Semantic dementia

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AN - SCOPUS:13844271183

SN - 0028-3932

VL - 43

SP - 833

EP - 846

JO - Neuropsychologia

JF - Neuropsychologia

IS - 6

ER -

Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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