Diffuse optical characterization of an exercising patient group with peripheral artery disease

Rickson C. Mesquita, Mary Putt, Malavika Chandra, Guoqiang Yu, Xiaoman Xing, Sung Wan Han, Gwen Lech, Yu Shang, Turgut Durduran, Chao Zhou, Arjun G. Yodh, Emile R. Mohler

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (StO2) has been demonstrated, this is the first study to assess both StO2 and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For StO2, mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean S tO2 is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of StO2 to baseline is more rapid in controls (p < 0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p < 0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p < 0.05). Additionally, relative rate of return to baseline StO2 is more rapid among subjects with reduced levels of depression in rBF (p = 0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies.

Original languageEnglish
Article number057007
JournalJournal of Biomedical Optics
Issue number5
StatePublished - May 2013

Bibliographical note

Funding Information:
The authors thank Ms. Xingmei Wang for assistance with statistical analysis, and Regine Choe for helpful discussions and feedback. This work was supported by the National Institutes of Health (NIH) through R01-NS060653 (AGY), P41-RR002305 (AGY), and R21-HL083225 (GY), by the American Heart Association through BGIA #0665446U (GY), by the FundacioCellex Barcelona (TD) and by the São Paulo Research Foundation (FAPESP) through 2012/02500-8 (RCM). A portion of ERM’s salary was supported via NIH National Heart, Lung and Blood Institute grant K12 HL083772-01. Disclosures: Patent (USA Patent #8082015, “Optical measurement of tissue blood flow hemodynamics and oxygenation”) granted on diffuse correlation spectroscopy (Yodh, Yu, Durduran, Mohler).


  • cardiovascular diseases
  • hemodynamics
  • muscle blood flow
  • near-infrared spectroscopy
  • peripheral artery disease

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Biomaterials


Dive into the research topics of 'Diffuse optical characterization of an exercising patient group with peripheral artery disease'. Together they form a unique fingerprint.

Cite this