TY - JOUR
T1 - Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
AU - Durduran, Turgut
AU - Yu, Guoqiang
AU - Burnett, Mark G.
AU - Detre, John A.
AU - Greenberg, Joel H.
AU - Wang, Jiongjiong
AU - Zhou, Chao
AU - Yodh, Arjun G.
PY - 2004/8/1
Y1 - 2004/8/1
N2 - We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods. The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored.
AB - We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods. The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored.
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U2 - 10.1364/OL.29.001766
DO - 10.1364/OL.29.001766
M3 - Article
C2 - 15352363
AN - SCOPUS:3943077212
VL - 29
SP - 1766
EP - 1768
IS - 15
ER -