Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes

Lixin Dong; Mahesh Kudrimoti; Daniel Irwin; Li Chen; Sameera Kumar; Yu Shang; Chong Huang; Ellis L. Johnson; Scott D. Stevens; Brent J. Shelton; Guoqiang Yua

doi:10.1117/1.JBO.21.8.085004

Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes

Lixin Dong, Mahesh Kudrimoti, Daniel Irwin, Li Chen, Sameera Kumar, Yu Shang, Chong Huang, Ellis L. Johnson, Scott D. Stevens, Brent J. Shelton, Guoqiang Yua

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n = 29) and incomplete response (IR) (n = 18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO₂]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO₂) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μ's ) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.

Original language	English
Article number	085004
Journal	Journal of Biomedical Optics
Volume	21
Issue number	8
DOIs	https://doi.org/10.1117/1.JBO.21.8.085004
State	Published - Aug 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).

Funding

This work was partially supported by the National Institutes of Health under Grant R01 CA149274 (GY), Grant R21 AR062356 (GY), Grant UL1RR033173 (GY), and the Biostatistics and Bioinformatics Shared Resource Facility of the University of Kentucky Markey Cancer Center (P30CA177558). We thank Dr. Tadahide Izumi for constructive discussion. We also thank Daniel Kameny, Jacqueline Sims, Karen Meekins, Laura Reichel, and Marta Wood for their assistance in recruitment of patients.

Funders	Funder number
The Markey Biostatistics and Bioinformatics Shared Resource Facility
National Institutes of Health (NIH)	UL1RR033173, R01 CA149274, R21 AR062356
National Childhood Cancer Registry – National Cancer Institute	P30CA177558
University of Kentucky Markey Cancer Center

Keywords

chemoradiation therapy
diffuse optics
head and neck cancer
near-infrared
papilloma virus status
tumor hemodynamics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/1.JBO.21.8.085004

Cite this

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title = "Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes",

abstract = "This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n = 29) and incomplete response (IR) (n = 18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μ's ) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.",

keywords = "chemoradiation therapy, diffuse optics, head and neck cancer, near-infrared, papilloma virus status, tumor hemodynamics",

author = "Lixin Dong and Mahesh Kudrimoti and Daniel Irwin and Li Chen and Sameera Kumar and Yu Shang and Chong Huang and Johnson, \{Ellis L.\} and Stevens, \{Scott D.\} and Shelton, \{Brent J.\} and Guoqiang Yua",

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AU - Dong, Lixin

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AU - Irwin, Daniel

AU - Chen, Li

AU - Kumar, Sameera

AU - Shang, Yu

AU - Huang, Chong

AU - Johnson, Ellis L.

AU - Stevens, Scott D.

AU - Shelton, Brent J.

AU - Yua, Guoqiang

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AB - This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n = 29) and incomplete response (IR) (n = 18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μ's ) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.

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KW - papilloma virus status

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Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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