TY - JOUR
T1 - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy
AU - Zhou, Chao
AU - Choe, Regine
AU - Shah, Natasha
AU - Durduran, Turgut
AU - Yu, Guoqiang
AU - Durkin, Amanda
AU - Hsiang, David
AU - Mehta, Rita
AU - Butler, John
AU - Cerussi, Albert
AU - Tromberg, Bruce J.
AU - Yodh, Arjun G.
PY - 2007/9
Y1 - 2007/9
N2 - We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.
AB - We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.
KW - Blood flow
KW - Breast cancer
KW - Diffuse correlation spectroscopy
KW - Diffuse optical spectroscopy
KW - Early monitoring
KW - Neoadjuvant chemotherapy
KW - Oxygen metabolism
UR - http://www.scopus.com/inward/record.url?scp=36249012737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36249012737&partnerID=8YFLogxK
U2 - 10.1117/1.2798595
DO - 10.1117/1.2798595
M3 - Article
C2 - 17994886
AN - SCOPUS:36249012737
SN - 1083-3668
VL - 12
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 5
M1 - 051903-1
ER -
