Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou; Regine Choe; Natasha Shah; Turgut Durduran; Guoqiang Yu; Amanda Durkin; David Hsiang; Rita Mehta; John Butler; Albert Cerussi; Bruce J. Tromberg; Arjun G. Yodh

doi:10.1117/1.2798595

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou, Regine Choe, Natasha Shah, Turgut Durduran, Guoqiang Yu, Amanda Durkin, David Hsiang, Rita Mehta, John Butler, Albert Cerussi, Bruce J. Tromberg, Arjun G. Yodh

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Abstract

We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb _T/N=69±21%), oxyhemoglobin (rctO2Hb_T/N= 73±25%), total hemoglobin (rctTHb_T/N=72±17%), and lipid concentration (rctLipid_T/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBF_T/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

Original language	English
Article number	051903-1
Journal	Journal of Biomedical Optics
Volume	12
Issue number	5
DOIs	https://doi.org/10.1117/1.2798595
State	Published - Sep 2007

Keywords

Blood flow
Breast cancer
Diffuse correlation spectroscopy
Diffuse optical spectroscopy
Early monitoring
Neoadjuvant chemotherapy
Oxygen metabolism

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/1.2798595

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title = "Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy",

abstract = "We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.",

keywords = "Blood flow, Breast cancer, Diffuse correlation spectroscopy, Diffuse optical spectroscopy, Early monitoring, Neoadjuvant chemotherapy, Oxygen metabolism",

author = "Chao Zhou and Regine Choe and Natasha Shah and Turgut Durduran and Guoqiang Yu and Amanda Durkin and David Hsiang and Rita Mehta and John Butler and Albert Cerussi and Tromberg, {Bruce J.} and Yodh, {Arjun G.}",

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T1 - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

AU - Zhou, Chao

AU - Choe, Regine

AU - Shah, Natasha

AU - Durduran, Turgut

AU - Yu, Guoqiang

AU - Durkin, Amanda

AU - Hsiang, David

AU - Mehta, Rita

AU - Butler, John

AU - Cerussi, Albert

AU - Tromberg, Bruce J.

AU - Yodh, Arjun G.

PY - 2007/9

Y1 - 2007/9

N2 - We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

AB - We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

KW - Blood flow

KW - Breast cancer

KW - Diffuse correlation spectroscopy

KW - Diffuse optical spectroscopy

KW - Early monitoring

KW - Neoadjuvant chemotherapy

KW - Oxygen metabolism

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Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Abstract

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