Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Chao Zhou, Regine Choe, Natasha Shah, Turgut Durduran, Guoqiang Yu, Amanda Durkin, David Hsiang, Rita Mehta, John Butler, Albert Cerussi, Bruce J. Tromberg, Arjun G. Yodh

Research output: Contribution to journalArticlepeer-review

169 Scopus citations

Abstract

We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N=69±21%), oxyhemoglobin (rctO2HbT/N= 73±25%), total hemoglobin (rctTHbT/N=72±17%), and lipid concentration (rctLipidT/N=116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBFT/N= 75±7% on day 7 with respect to day 0). Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms.

Original languageEnglish
Article number051903-1
JournalJournal of Biomedical Optics
Volume12
Issue number5
DOIs
StatePublished - Sep 2007

Keywords

  • Blood flow
  • Breast cancer
  • Diffuse correlation spectroscopy
  • Diffuse optical spectroscopy
  • Early monitoring
  • Neoadjuvant chemotherapy
  • Oxygen metabolism

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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