Dinutuximab for maintenance therapy in pediatric neuroblastoma

Lauren McGinty, Jill Kolesar

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Purpose. The pharmacology, clinical efficacy, safety, dosage and administration, and role in therapy of dinutuximab for the treatment of high-risk pediatric neuroblastoma are reviewed. Summary. Dinutuximab (Unituxin, United Therapeutics) is a novel monoclonal antibody recently approved for use in combination with granulocyte- macrophage colony-stimulating factor, interleukin-2, and isotretinoin for the treatment of pediatric patients with high-risk neuroblastoma. Its approval has led to the first major change in standard recommended first-line maintenance therapy for high-risk pediatric neuroblastoma in over a decade. Dinutuximab causes antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity by binding to GD2, a tumor-Associated antigen. The recommended dosage of dinutuximab is 17.5 mg/ m2/day for 4 consecutive days of each 24- or 32-day cycle, for a maximum of 5 cycles. In a Phase III trial, patients who received dinutuximab as part of combination immunotherapy in addition to standard maintenance therapy had significantly improved 2-year event-free survival relative to those who received standard maintenance therapy alone (66% versus 46%, p < 0.01). Dinutuximab has a unique adverse-effect profile that includes infusion reactions, neuropathic pain, and electrolyte abnormalities; the most common adverse effects observed with dinutuximab use in clinical trials were pain, pyrexia, myelosuppression, infusion reactions, and electrolyte abnormalities. Conclusion. Dinutuximab is a novel monoclonal antibody that is efficacious as part of combination immunotherapy in pediatric patients with high-risk neuroblastoma.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalAmerican Journal of Health-System Pharmacy
Issue number8
StatePublished - Apr 15 2017

Bibliographical note

Publisher Copyright:
©2017, American Society of Health-System Pharmacists, Inc. All rights reserved.


  • Dinutuximab
  • Neuroblastoma

ASJC Scopus subject areas

  • Pharmacy
  • Pharmacology
  • Health Policy


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