Direct endoscopic necrosectomy versus step-up approach for walled-off pancreatic necrosis comparison of clinical outcome and health care utilization

Nitin Kumar, Darwin L. Conwell, Christopher C. Thompson

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Objectives: Infected walled-off pancreatic necrosis (WOPN) is a complication of acute pancreatitis requiring intervention. Surgery is associated with considerable morbidity. Percutaneous catheter drainage (PCD), initial therapy in the step-up approach, minimizes complications. Direct endo-scopic necrosectomy (DEN) has demonstrated safety and efficacy. We compared outcome and health care utilization of DEN versus step-up approach.

Methods: This was a matched cohort study using a prospective registry. Twelve consecutive DEN patients were matched with 12 step-up approach patients. Outcomes were clinical resolution after primary therapeutic modality, new organ failure, mortality, endocrine or exocrine insufficiency, length of stay, and health care utilization.

Results: Clinical resolution in 11 of 12 patients after DEN versus 3 of 12 step-up approach patients after PCD (P < 0.01). Nine step-up approach patients required surgery; 7 of these experienced complications. Direct endo-scopic necrosectomy resulted in less new antibiotic use, pulmonary failure, endocrine insufficiency, and shorter length of stay (P < 0.05). Health care utilization was lower after DEN by 5.2:1 (P < 0.01).

Conclusions: Direct endoscopic necrosectomy may be superior to step-up approach for WOPN with suspected or established infection. Primary PCD generally delayed definitive therapy. Given the higher efficacy, shorter length of stay, and lower health care utilization, DEN could be the first-line therapy for WOPN, with primary PCD for inaccessible or immature collections.

Original languageEnglish
Pages (from-to)1334-1339
Number of pages6
JournalPancreas
Volume43
Issue number8
DOIs
StatePublished - Nov 10 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 by Lippincott Williams & Wilkins.

Keywords

  • Endoscopic necrosectomy
  • Endoscopy
  • Pancreatic necrosis
  • Step-up approach

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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