Direct measurement of tissue blood flow and metabolism with diffuse optics

Rickson C. Mesquita, Turgut Durduran, Guoqiang Yu, Erin M. Buckley, Meeri N. Kim, Chao Zhou, Regine Choe, Ulas Sunar, Arjun G. Yodh

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


Diffuse optics has proven useful for quantitative assessment of tissue oxy- and deoxyhaemoglobin concentrations and, more recently, for measurement of microvascular blood flow. In this paper, we focus on the flow monitoring technique: diffuse correlation spectroscopy (DCS). Representative clinical and pre-clinical studies from our laboratory illustrate the potential of DCS. Validation of DCS blood flow indices in human brain and muscle is presented. Comparison of DCS with arterial spin-labelled MRI, xenon-CT and Doppler ultrasound shows good agreement (0.50<r <0.95) over a wide range of tissue types and source detector distances, corroborating the potential of the method to measure perfusion non-invasively and in vivo at the microvasculature level. Alloptical measurements of cerebral oxygen metabolism in both rat brain, following middle cerebral artery occlusion, and human brain, during functional activation, are also described. In both situations, the use of combined DCS and diffuse optical spectroscopy/near-infrared spectroscopy to monitor changes in oxygen consumption by the tissue is demonstrated. Finally, recent results spanning from gene expression-induced angiogenic response to stroke care and cancer treatment monitoring are discussed. Collectively, the research illustrates the capability of DCS to quantitatively monitor perfusion from bench to bedside, providing results that match up both with literature findings and with similar experiments performed with other techniques. This journal is

Original languageEnglish
Pages (from-to)4390-4406
Number of pages17
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number1955
StatePublished - Nov 28 2011


  • Blood flow
  • Brain
  • Cancer
  • Cerebral blood flow
  • Diffuse correlation spectroscopy
  • Oxygen metabolism

ASJC Scopus subject areas

  • General Mathematics
  • General Engineering
  • General Physics and Astronomy


Dive into the research topics of 'Direct measurement of tissue blood flow and metabolism with diffuse optics'. Together they form a unique fingerprint.

Cite this