Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis

Thangaiah Subramanian; Zhongwen Wang; Jerry M. Troutman; Douglas A. Andres; H. Peter Spielmann

doi:10.1021/ol050386o

Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis

Thangaiah Subramanian, Zhongwen Wang, Jerry M. Troutman, Douglas A. Andres, H. Peter Spielmann

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17 Scopus citations

Abstract

(Chemical Equation Presented) A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)₄N)₃HP₂O₇

Original language	English
Pages (from-to)	2109-2112
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/ol050386o
State	Published - May 26 2005

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol050386o

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abstract = "(Chemical Equation Presented) A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)4N)3HP2O7",

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AU - Wang, Zhongwen

AU - Troutman, Jerry M.

AU - Andres, Douglas A.

AU - Spielmann, H. Peter

PY - 2005/5/26

Y1 - 2005/5/26

N2 - (Chemical Equation Presented) A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)4N)3HP2O7

AB - (Chemical Equation Presented) A directed library of anilinogeranyl diphosphate analogues of the isoprenoid farnesyl diphosphate has been prepared by solid-phase organic synthesis using a traceless linker strategy in moderate yield in three steps: reductive amination, bromination, and treatment with ((n-Bu)4N)3HP2O7

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Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis

Abstract

ASJC Scopus subject areas

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