Discovery and development of novel substituted monohydrazides as potent antifungal agents

Nishad Thamban Chandrika; Keith D. Green; Abbygail C. Spencer; Oleg V. Tsodikov; Sylvie Garneau-Tsodikova

doi:10.1039/d3md00167a

Discovery and development of novel substituted monohydrazides as potent antifungal agents

Nishad Thamban Chandrika, Keith D. Green, Abbygail C. Spencer, Oleg V. Tsodikov, Sylvie Garneau-Tsodikova

Research output: Contribution to journal › Article › peer-review

Abstract

Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.

Original language	English
Pages (from-to)	1351-1361
Number of pages	11
Journal	RSC Medicinal Chemistry
Volume	14
Issue number	7
DOIs	https://doi.org/10.1039/d3md00167a
State	Published - Jun 14 2023

Bibliographical note

Publisher Copyright:
© 2023 RSC.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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title = "Discovery and development of novel substituted monohydrazides as potent antifungal agents",

abstract = "Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.",

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AU - Garneau-Tsodikova, Sylvie

PY - 2023/6/14

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N2 - Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.

AB - Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.

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Discovery and development of novel substituted monohydrazides as potent antifungal agents

Abstract

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