Abstract
Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.
| Original language | English |
|---|---|
| Pages (from-to) | 1351-1361 |
| Number of pages | 11 |
| Journal | RSC Medicinal Chemistry |
| Volume | 14 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jun 14 2023 |
Bibliographical note
Publisher Copyright:© 2023 RSC.
Funding
Some NMR data reported in this publication were recorded on a Bruker AVANCE NEO 600 MHz high-performance digital NMR spectrometer supported by a NIH S10 grant S10OD28690 (to S. G.-T.). We thank the University of Kentucky PharmNMR Center (in the College of Pharmacy) for NMR support.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | S10OD28690 |
| National Institutes of Health (NIH) | |
| University of Kentucky |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry