TY - JOUR
T1 - Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound
AU - Mirzoeva, Salida
AU - Sawkar, Anu
AU - Zasadzki, Magdalena
AU - Guo, Ling
AU - Velentza, Anastasia V.
AU - Dunlap, Vincent
AU - Bourguignonl, Jean Jacques
AU - Ramstrom, Helena
AU - Haiech, Jacques
AU - Van Eldik, Linda J.
AU - Watterson, D. M.
PY - 2002/1/31
Y1 - 2002/1/31
N2 - Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1β, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.
AB - Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1β, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.
UR - https://www.scopus.com/pages/publications/0037204008
UR - https://www.scopus.com/pages/publications/0037204008#tab=citedBy
U2 - 10.1021/jm015573g
DO - 10.1021/jm015573g
M3 - Article
C2 - 11806708
AN - SCOPUS:0037204008
SN - 0022-2623
VL - 45
SP - 563
EP - 566
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 3
ER -