Discovery of common chemical exposures across three continents using silicone wristbands

Holly M. Dixon; Georgina Armstrong; Michael Barton; Alan J. Bergmann; Melissa Bondy; Mary L. Halbleib; Winifred Hamilton; Erin Haynes; Julie Herbstman; Peter Hoffman; Paul Jepson; Molly L. Kile; Laurel Kincl; Paul J. Laurienti; Paula North; L. Blair Paulik; Joe Petrosino; Gary L. Points; Carolyn M. Poutasse; Diana Rohlman; Richard P. Scott; Brian Smith; Lane G. Tidwell; Cheryl Walker; Katrina M. Waters; Kim A. Anderson

doi:10.1098/rsos.181836

Discovery of common chemical exposures across three continents using silicone wristbands

Holly M. Dixon, Georgina Armstrong, Michael Barton, Alan J. Bergmann, Melissa Bondy, Mary L. Halbleib, Winifred Hamilton, Erin Haynes, Julie Herbstman, Peter Hoffman, Paul Jepson, Molly L. Kile, Laurel Kincl, Paul J. Laurienti, Paula North, L. Blair Paulik, Joe Petrosino, Gary L. Points, Carolyn M. Poutasse, Diana RohlmanRichard P. Scott, Brian Smith, Lane G. Tidwell, Cheryl Walker, Katrina M. Waters, Kim A. Anderson

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10 - 25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36 - 53% and 18 - 42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.

Original language	English
Article number	181836
Journal	Royal Society Open Science
Volume	6
Issue number	2
DOIs	https://doi.org/10.1098/rsos.181836
State	Published - Feb 1 2019

Bibliographical note

Funding Information:
Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830.

Funding Information:
G.A., M.B., W.H., J.P. and C.W. assisted with organizing the Texas wristband study. K.M.W., L.K. and J.H. conceived and designed the New York and Eugene wristband studies. M.B. helped with data management and created the network analysis visualization. B.S. provided statistical advice, generated the data for the Venn diagram tables and performed principal component analysis. G.L.P. and R.P.S. helped with all wristband preparation and analysis. K.A.A. conceived and designed this study and oversaw all chemical analyses. All authors reviewed and edited the manuscript, and gave their final approval for publication. Competing interests. K.A.A. and D.R., authors of this research, disclose a financial interest in MyExposome, Inc., which is marketing products related to the research being reported. The terms of this arrangement have been reviewed and approved by OSU in accordance with its policy on research conflicts of interest. The authors have no other disclosures. Funding. Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Acknowledgements. We wish to thank the volunteer participants in this study. From Oregon State University’s Food Safety and Environmental Stewardship Program, we thank Glenn Wilson, Steven O’Connell, Christine Ghetu, Rachel Liu-May, Clarisa Caballero-Ignacio, Ian Moran, Jessica Scotten, Jorge Padilla, Melissa McCartney, Josh Willmarth and Amber Barnard. We acknowledge Carey Donald for her work with the wristbands from Senegal. We thank Sara A. Quandt and Thomas A. Arcury from Wake Forest for their help with North Carolina and South Africa wristbands, and Hanna-Andrea Rother from the University of Cape Town for help with the collection of the South Africa wristbands. We acknowledge Darrell Holmes and Lehyla Calero for their help with the collection of wristbands in New York. We acknowledge Jackie Young, Robin Fuchs-Young, Madison Spier, Oluwatosin Bewaji, Gustavo Elizondo and the staff of Texas Health and Environment Alliance, Inc. for organizational support in Houston, Texas. For the wristband project in Ohio, we thank Paul Feezel, Kevin Hobbie, Sarah Elam, Delores Silverthorn, David Brown, Jody Alden and Pierce Kuhnell. We also acknowledge Lisa Arkin for her assistance with the Eugene project.

Publisher Copyright:
© 2019 The Authors.

Keywords

Chemical mixtures
Endocrine disruptor chemicals
Exposure science
Flame retardants
Phthalates
Semivolatile organic compounds

ASJC Scopus subject areas

General

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10.1098/rsos.181836

Cite this

Dixon, H. M., Armstrong, G., Barton, M., Bergmann, A. J., Bondy, M., Halbleib, M. L., Hamilton, W., Haynes, E., Herbstman, J., Hoffman, P., Jepson, P., Kile, M. L., Kincl, L., Laurienti, P. J., North, P., Blair Paulik, L., Petrosino, J., Points, G. L., Poutasse, C. M., ... Anderson, K. A. (2019). Discovery of common chemical exposures across three continents using silicone wristbands. Royal Society Open Science, 6(2), [181836]. https://doi.org/10.1098/rsos.181836

@article{3a92f1682f9f4f2198ddd68eb18d417e,

title = "Discovery of common chemical exposures across three continents using silicone wristbands",

abstract = "To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10 - 25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36 - 53% and 18 - 42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.",

keywords = "Chemical mixtures, Endocrine disruptor chemicals, Exposure science, Flame retardants, Phthalates, Semivolatile organic compounds",

author = "Dixon, {Holly M.} and Georgina Armstrong and Michael Barton and Bergmann, {Alan J.} and Melissa Bondy and Halbleib, {Mary L.} and Winifred Hamilton and Erin Haynes and Julie Herbstman and Peter Hoffman and Paul Jepson and Kile, {Molly L.} and Laurel Kincl and Laurienti, {Paul J.} and Paula North and {Blair Paulik}, L. and Joe Petrosino and Points, {Gary L.} and Poutasse, {Carolyn M.} and Diana Rohlman and Scott, {Richard P.} and Brian Smith and Tidwell, {Lane G.} and Cheryl Walker and Waters, {Katrina M.} and Anderson, {Kim A.}",

note = "Funding Information: Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Funding Information: G.A., M.B., W.H., J.P. and C.W. assisted with organizing the Texas wristband study. K.M.W., L.K. and J.H. conceived and designed the New York and Eugene wristband studies. M.B. helped with data management and created the network analysis visualization. B.S. provided statistical advice, generated the data for the Venn diagram tables and performed principal component analysis. G.L.P. and R.P.S. helped with all wristband preparation and analysis. K.A.A. conceived and designed this study and oversaw all chemical analyses. All authors reviewed and edited the manuscript, and gave their final approval for publication. Competing interests. K.A.A. and D.R., authors of this research, disclose a financial interest in MyExposome, Inc., which is marketing products related to the research being reported. The terms of this arrangement have been reviewed and approved by OSU in accordance with its policy on research conflicts of interest. The authors have no other disclosures. Funding. Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Acknowledgements. We wish to thank the volunteer participants in this study. From Oregon State University{\textquoteright}s Food Safety and Environmental Stewardship Program, we thank Glenn Wilson, Steven O{\textquoteright}Connell, Christine Ghetu, Rachel Liu-May, Clarisa Caballero-Ignacio, Ian Moran, Jessica Scotten, Jorge Padilla, Melissa McCartney, Josh Willmarth and Amber Barnard. We acknowledge Carey Donald for her work with the wristbands from Senegal. We thank Sara A. Quandt and Thomas A. Arcury from Wake Forest for their help with North Carolina and South Africa wristbands, and Hanna-Andrea Rother from the University of Cape Town for help with the collection of the South Africa wristbands. We acknowledge Darrell Holmes and Lehyla Calero for their help with the collection of wristbands in New York. We acknowledge Jackie Young, Robin Fuchs-Young, Madison Spier, Oluwatosin Bewaji, Gustavo Elizondo and the staff of Texas Health and Environment Alliance, Inc. for organizational support in Houston, Texas. For the wristband project in Ohio, we thank Paul Feezel, Kevin Hobbie, Sarah Elam, Delores Silverthorn, David Brown, Jody Alden and Pierce Kuhnell. We also acknowledge Lisa Arkin for her assistance with the Eugene project. Publisher Copyright: {\textcopyright} 2019 The Authors.",

year = "2019",

month = feb,

day = "1",

doi = "10.1098/rsos.181836",

language = "English",

volume = "6",

number = "2",

}

Dixon, HM, Armstrong, G, Barton, M, Bergmann, AJ, Bondy, M, Halbleib, ML, Hamilton, W, Haynes, E, Herbstman, J, Hoffman, P, Jepson, P, Kile, ML, Kincl, L, Laurienti, PJ, North, P, Blair Paulik, L, Petrosino, J, Points, GL, Poutasse, CM, Rohlman, D, Scott, RP, Smith, B, Tidwell, LG, Walker, C, Waters, KM & Anderson, KA 2019, 'Discovery of common chemical exposures across three continents using silicone wristbands', Royal Society Open Science, vol. 6, no. 2, 181836. https://doi.org/10.1098/rsos.181836

TY - JOUR

T1 - Discovery of common chemical exposures across three continents using silicone wristbands

AU - Dixon, Holly M.

AU - Armstrong, Georgina

AU - Barton, Michael

AU - Bergmann, Alan J.

AU - Bondy, Melissa

AU - Halbleib, Mary L.

AU - Hamilton, Winifred

AU - Haynes, Erin

AU - Herbstman, Julie

AU - Hoffman, Peter

AU - Jepson, Paul

AU - Kile, Molly L.

AU - Kincl, Laurel

AU - Laurienti, Paul J.

AU - North, Paula

AU - Blair Paulik, L.

AU - Petrosino, Joe

AU - Points, Gary L.

AU - Poutasse, Carolyn M.

AU - Rohlman, Diana

AU - Scott, Richard P.

AU - Smith, Brian

AU - Tidwell, Lane G.

AU - Walker, Cheryl

AU - Waters, Katrina M.

AU - Anderson, Kim A.

N1 - Funding Information: Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Funding Information: G.A., M.B., W.H., J.P. and C.W. assisted with organizing the Texas wristband study. K.M.W., L.K. and J.H. conceived and designed the New York and Eugene wristband studies. M.B. helped with data management and created the network analysis visualization. B.S. provided statistical advice, generated the data for the Venn diagram tables and performed principal component analysis. G.L.P. and R.P.S. helped with all wristband preparation and analysis. K.A.A. conceived and designed this study and oversaw all chemical analyses. All authors reviewed and edited the manuscript, and gave their final approval for publication. Competing interests. K.A.A. and D.R., authors of this research, disclose a financial interest in MyExposome, Inc., which is marketing products related to the research being reported. The terms of this arrangement have been reviewed and approved by OSU in accordance with its policy on research conflicts of interest. The authors have no other disclosures. Funding. Research reported in this publication was supported by the National Institute of Environmental Health Sciences (NIEHS) under award numbers P42 ES012016465, P20 ES000210, R21 ES020120, R33 ES024718, R24 TW009550, P30 ES000210, P30 ES006096 and R01 ES008739. H.M.D. was supported in part by NIEHS Fellowship T32 ES007060 and ARCS Foundationw Oregon. Pacific Northwest National Laboratory is a multi-program national laboratory operated by Battelle for the U.S. Department of Energy under Contract DE-AC05-76RL01830. Acknowledgements. We wish to thank the volunteer participants in this study. From Oregon State University’s Food Safety and Environmental Stewardship Program, we thank Glenn Wilson, Steven O’Connell, Christine Ghetu, Rachel Liu-May, Clarisa Caballero-Ignacio, Ian Moran, Jessica Scotten, Jorge Padilla, Melissa McCartney, Josh Willmarth and Amber Barnard. We acknowledge Carey Donald for her work with the wristbands from Senegal. We thank Sara A. Quandt and Thomas A. Arcury from Wake Forest for their help with North Carolina and South Africa wristbands, and Hanna-Andrea Rother from the University of Cape Town for help with the collection of the South Africa wristbands. We acknowledge Darrell Holmes and Lehyla Calero for their help with the collection of wristbands in New York. We acknowledge Jackie Young, Robin Fuchs-Young, Madison Spier, Oluwatosin Bewaji, Gustavo Elizondo and the staff of Texas Health and Environment Alliance, Inc. for organizational support in Houston, Texas. For the wristband project in Ohio, we thank Paul Feezel, Kevin Hobbie, Sarah Elam, Delores Silverthorn, David Brown, Jody Alden and Pierce Kuhnell. We also acknowledge Lisa Arkin for her assistance with the Eugene project. Publisher Copyright: © 2019 The Authors.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10 - 25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36 - 53% and 18 - 42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.

AB - To assess differences and trends in personal chemical exposure, volunteers from 14 communities in Africa (Senegal, South Africa), North America (United States (U.S.)) and South America (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting in 400 860 chemical data points. The number of chemical detections ranged from 4 to 43 per wristband, with 191 different chemicals detected, and 1339 chemicals were not detected in any wristband. No two wristbands had identical chemical detections. We detected 13 potential endocrine disrupting chemicals in over 50% of all wristbands and found 36 chemicals in common between chemicals detected in three geographical wristband groups (Africa, North America and South America). U.S. children (less than or equal to 11 years) had the highest percentage of flame retardant detections compared with all other participants. Wristbands worn in Texas post-Hurricane Harvey had the highest mean number of chemical detections (28) compared with other study locations (10 - 25). Consumer product-related chemicals and phthalates were a high percentage of chemical detections across all study locations (36 - 53% and 18 - 42%, respectively). Chemical exposures varied among individuals; however, many individuals were exposed to similar chemical mixtures. Our exploratory investigation uncovered personal chemical exposure trends that can help prioritize certain mixtures and chemical classes for future studies.

KW - Chemical mixtures

KW - Endocrine disruptor chemicals

KW - Exposure science

KW - Flame retardants

KW - Phthalates

KW - Semivolatile organic compounds

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ER -

Discovery of common chemical exposures across three continents using silicone wristbands

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