Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis

Jong Yeon Hwang, David Smithson, Michele Connelly, Julie Maier, Fangyi Zhu, Kiplin R. Guy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
StatePublished - Jan 1 2010

Bibliographical note

Funding Information:
This work was supported by the American Lebanese Syrian Associated Charities (ALSAC) and St. Jude Children’s Research Hospital.


  • HAT
  • Inhibitor
  • Trypanosomiasis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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