Diseases caused by silica: Mechanisms of injury and disease development

Min Ding, Fei Chen, Xianglin Shi, Berran Yucesoy, Brooke Mossman, Val Vallyathan

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations

Abstract

While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-κB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-α. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed.

Original languageEnglish
Pages (from-to)173-182
Number of pages10
JournalInternational Immunopharmacology
Volume2
Issue number2-3
DOIs
StatePublished - 2002

Keywords

  • NF-κB
  • Reactive oxygen species
  • Silica

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Diseases caused by silica: Mechanisms of injury and disease development'. Together they form a unique fingerprint.

Cite this