TY - JOUR
T1 - Diseases caused by silica
T2 - Mechanisms of injury and disease development
AU - Ding, Min
AU - Chen, Fei
AU - Shi, Xianglin
AU - Yucesoy, Berran
AU - Mossman, Brooke
AU - Vallyathan, Val
PY - 2002
Y1 - 2002
N2 - While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-κB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-α. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed.
AB - While silica particles are considered to be fibrogenic and carcinogenic agents, the mechanisms responsible are not well understood. This article summarizes literature on silica-induced accelerated silicosis, chronic silicosis, silico-tuberculosis, bronchogenic carcinoma, and immune-mediated diseases. This article also discusses the generation of reactive oxygen species (ROS) that occurs directly from the interaction of silica with aqueous medium and from silica-stimulated cells, the molecular mechanisms of silica-induced lung injuries with focus on silica-induced NF-κB activation, including its mechanisms, possible attenuation and relationship to silica-induced generation of cyclooxygenase II and TNF-α. Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed.
KW - NF-κB
KW - Reactive oxygen species
KW - Silica
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U2 - 10.1016/S1567-5769(01)00170-9
DO - 10.1016/S1567-5769(01)00170-9
M3 - Review article
C2 - 11811922
AN - SCOPUS:0036147520
SN - 1567-5769
VL - 2
SP - 173
EP - 182
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 2-3
ER -