Disruption of the mouse cyclooxygenase 1 gene: Characteristics of the mutant and areas of future study

Robert Langenbach, Scott G. Morham, Howard F. Tiano, Charles D. Loftin, Burhan I. Ghanayem, Patrica C. Chulada, Joel F. Mahler, Barbara J. Davis, Christopher A. Lee

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume407
StatePublished - 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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