Disruption of the mouse cyclooxygenase 1 gene: Characteristics of the mutant and areas of future study

Robert Langenbach; Scott G. Morham; Howard F. Tiano; Charles D. Loftin; Burhan I. Ghanayem; Patrica C. Chulada; Joel F. Mahler; Barbara J. Davis; Christopher A. Lee

Disruption of the mouse cyclooxygenase 1 gene: Characteristics of the mutant and areas of future study

Robert Langenbach, Scott G. Morham, Howard F. Tiano, Charles D. Loftin, Burhan I. Ghanayem, Patrica C. Chulada, Joel F. Mahler, Barbara J. Davis, Christopher A. Lee

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.

Original language	English
Pages (from-to)	87-92
Number of pages	6
Journal	Advances in Experimental Medicine and Biology
Volume	407
State	Published - 1996

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Cite this

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title = "Disruption of the mouse cyclooxygenase 1 gene: Characteristics of the mutant and areas of future study",

abstract = "Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.",

author = "Robert Langenbach and Morham, {Scott G.} and Tiano, {Howard F.} and Loftin, {Charles D.} and Ghanayem, {Burhan I.} and Chulada, {Patrica C.} and Mahler, {Joel F.} and Davis, {Barbara J.} and Lee, {Christopher A.}",

year = "1996",

language = "English",

volume = "407",

pages = "87--92",

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T1 - Disruption of the mouse cyclooxygenase 1 gene

T2 - Characteristics of the mutant and areas of future study

AU - Langenbach, Robert

AU - Morham, Scott G.

AU - Tiano, Howard F.

AU - Loftin, Charles D.

AU - Ghanayem, Burhan I.

AU - Chulada, Patrica C.

AU - Mahler, Joel F.

AU - Davis, Barbara J.

AU - Lee, Christopher A.

PY - 1996

Y1 - 1996

N2 - Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.

AB - Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.

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AN - SCOPUS:0030417714

SN - 0065-2598

VL - 407

SP - 87

EP - 92

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Disruption of the mouse cyclooxygenase 1 gene: Characteristics of the mutant and areas of future study

Abstract

ASJC Scopus subject areas

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