Disruption of zinc homeostasis in Alzheimer's disease

J. D. Robertson; A. M. Crafford; W. R. Markesbery; M. A. Lovell

doi:10.1016/S0168-583X(01)01124-7

Disruption of zinc homeostasis in Alzheimer's disease

J. D. Robertson, A. M. Crafford, W. R. Markesbery, M. A. Lovell

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The basic hypothesis being tested is that, in Alzheimer's disease (AD), the delicate balance of brain Zn is disrupted and may play a role in the pathogenesis of neuron degeneration. Micro-PIXE measurements reveal a significant elevation of Zn in senile plaques (SP) in AD brain compared with adjacent neuropil and a significant increase in AD neuropil compared to control neuropil. The observation of elevated Zn in SP is of interest because the amyloid precursor protein contains a Zn binding site that may prevent normal cleavage leading to the generation of a toxic fragment of beta amyloid, the constituent of SP. The potential of using laser-ablation inductively coupled plasma mass spectrometry as a complimentary microprobe technique is also presented.

Original language	English
Pages (from-to)	454-458
Number of pages	5
Journal	Nuclear Inst. and Methods in Physics Research, B
Volume	189
Issue number	1-4
DOIs	https://doi.org/10.1016/S0168-583X(01)01124-7
State	Published - Apr 2002

Bibliographical note

Funding Information:
Funding for this work was provided by NIH Grants 5-P01-AG05119, 5-P50-AG05144 and 1R01-AG16269 and by a grant from the Abercrobmie Foundation. The authors thank Ela Patel for tissue immunostaining and Barry Higgins for assistance with the LA-ICP-MS measurements.

Keywords

Alzheimer's disease
Brain
LA-ICP-MS
Micro-PIXE
Zinc

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/S0168-583X(01)01124-7

Cite this

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title = "Disruption of zinc homeostasis in Alzheimer's disease",

abstract = "The basic hypothesis being tested is that, in Alzheimer's disease (AD), the delicate balance of brain Zn is disrupted and may play a role in the pathogenesis of neuron degeneration. Micro-PIXE measurements reveal a significant elevation of Zn in senile plaques (SP) in AD brain compared with adjacent neuropil and a significant increase in AD neuropil compared to control neuropil. The observation of elevated Zn in SP is of interest because the amyloid precursor protein contains a Zn binding site that may prevent normal cleavage leading to the generation of a toxic fragment of beta amyloid, the constituent of SP. The potential of using laser-ablation inductively coupled plasma mass spectrometry as a complimentary microprobe technique is also presented.",

keywords = "Alzheimer's disease, Brain, LA-ICP-MS, Micro-PIXE, Zinc",

author = "Robertson, {J. D.} and Crafford, {A. M.} and Markesbery, {W. R.} and Lovell, {M. A.}",

note = "Funding Information: Funding for this work was provided by NIH Grants 5-P01-AG05119, 5-P50-AG05144 and 1R01-AG16269 and by a grant from the Abercrobmie Foundation. The authors thank Ela Patel for tissue immunostaining and Barry Higgins for assistance with the LA-ICP-MS measurements.",

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AU - Crafford, A. M.

AU - Markesbery, W. R.

AU - Lovell, M. A.

N1 - Funding Information: Funding for this work was provided by NIH Grants 5-P01-AG05119, 5-P50-AG05144 and 1R01-AG16269 and by a grant from the Abercrobmie Foundation. The authors thank Ela Patel for tissue immunostaining and Barry Higgins for assistance with the LA-ICP-MS measurements.

PY - 2002/4

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N2 - The basic hypothesis being tested is that, in Alzheimer's disease (AD), the delicate balance of brain Zn is disrupted and may play a role in the pathogenesis of neuron degeneration. Micro-PIXE measurements reveal a significant elevation of Zn in senile plaques (SP) in AD brain compared with adjacent neuropil and a significant increase in AD neuropil compared to control neuropil. The observation of elevated Zn in SP is of interest because the amyloid precursor protein contains a Zn binding site that may prevent normal cleavage leading to the generation of a toxic fragment of beta amyloid, the constituent of SP. The potential of using laser-ablation inductively coupled plasma mass spectrometry as a complimentary microprobe technique is also presented.

AB - The basic hypothesis being tested is that, in Alzheimer's disease (AD), the delicate balance of brain Zn is disrupted and may play a role in the pathogenesis of neuron degeneration. Micro-PIXE measurements reveal a significant elevation of Zn in senile plaques (SP) in AD brain compared with adjacent neuropil and a significant increase in AD neuropil compared to control neuropil. The observation of elevated Zn in SP is of interest because the amyloid precursor protein contains a Zn binding site that may prevent normal cleavage leading to the generation of a toxic fragment of beta amyloid, the constituent of SP. The potential of using laser-ablation inductively coupled plasma mass spectrometry as a complimentary microprobe technique is also presented.

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KW - LA-ICP-MS

KW - Micro-PIXE

KW - Zinc

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Disruption of zinc homeostasis in Alzheimer's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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