Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Kannan Badri Narayanan, Manaf Ali, Barry J. Barclay, Qiang Cheng, Leandro D'Abronzo, Rita Dornetshuber-Fleiss, Paramita M. Ghosh, Michael J. Gonzalez Guzman, Tae Jin Lee, Po Sing Leung, Lin Li, Suidjit Luanpitpong, Edward Ratovitski, Yon Rojanasakul, Maria Fiammetta Romano, Simona Romano, Ranjeet Kumar Sinha, Clement Yedjou, Fahd Al-Mulla, Rabeah Al-TemaimiAmedeo Amedei, Dustin G. Brown, Elizabeth P. Ryan, Annamaria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Hosni K. Salem, Jordan Woodrick, Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Seo Yun Kim, William H. Bisson, Leroy Lowe, Hyun Ho Park

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.

Original languageEnglish
Pages (from-to)S89-S110
StatePublished - Jun 1 2015

Bibliographical note

Publisher Copyright:
© The Author 2015.

ASJC Scopus subject areas

  • Cancer Research


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