TY - JOUR
T1 - Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
AU - Narayanan, Kannan Badri
AU - Ali, Manaf
AU - Barclay, Barry J.
AU - Cheng, Qiang
AU - D'Abronzo, Leandro
AU - Dornetshuber-Fleiss, Rita
AU - Ghosh, Paramita M.
AU - Gonzalez Guzman, Michael J.
AU - Lee, Tae Jin
AU - Leung, Po Sing
AU - Li, Lin
AU - Luanpitpong, Suidjit
AU - Ratovitski, Edward
AU - Rojanasakul, Yon
AU - Romano, Maria Fiammetta
AU - Romano, Simona
AU - Sinha, Ranjeet Kumar
AU - Yedjou, Clement
AU - Al-Mulla, Fahd
AU - Al-Temaimi, Rabeah
AU - Amedei, Amedeo
AU - Brown, Dustin G.
AU - Ryan, Elizabeth P.
AU - Colacci, Annamaria
AU - Hamid, Roslida A.
AU - Mondello, Chiara
AU - Raju, Jayadev
AU - Salem, Hosni K.
AU - Woodrick, Jordan
AU - Scovassi, Ivana
AU - Singh, Neetu
AU - Vaccari, Monica
AU - Roy, Rabindra
AU - Forte, Stefano
AU - Memeo, Lorenzo
AU - Kim, Seo Yun
AU - Bisson, William H.
AU - Lowe, Leroy
AU - Park, Hyun Ho
N1 - Publisher Copyright:
© The Author 2015.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
AB - Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.
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U2 - 10.1093/carcin/bgv032
DO - 10.1093/carcin/bgv032
M3 - Review article
C2 - 26106145
AN - SCOPUS:84937698903
SN - 0143-3334
VL - 36
SP - S89-S110
JO - Carcinogenesis
JF - Carcinogenesis
ER -
