TY - JOUR
T1 - Dissociation of coronary artery contractile hyperreactivity from hypertension
AU - Su, Wen
AU - Guo, Zhenheng
AU - Deschepper, Christian F.
AU - Randall, David C.
AU - Gong, Ming C.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Background: Both coronary artery contractile hyperreactivity and hypertension are associated with increased coronary artery disease. It is not known how coronary artery contractile hyperreactivity relates to hypertension. The current study tests the hypothesis that coronary artery contractile hyperreactivity can be dissociated from hypertension and therefore may contribute to the etiology of CAD independent of hypertension. Methods: The contractile responses to 5-hydroxytryptamine (5-HT) and guanosine triphosphate (GTP) were determined in intact (nonpermeabilized) and α-toxin-permeabilized coronary artery strips and small mesenteric artery strips isolated from four rat strains: spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), WKY-derived hypertensive rats (WKHT), and WKY-derived hyperactive rats (WKHA). Results: The SHR and WKHT were hypertensive, whereas the WKY and WKHA subjects were normotensire. The coronary artery contractile reactivity to 5-HT was significantly higher in SHR when compared with WKY. The coronary artery contractile reactivity was of similar magnitude in WKHA and WKHT and was intermediate between that of SHR and WKY rats. GTP-induced Ca2+ sensitization of contractions were significantly greater in SHR than in WKHT, WKHA, and WKY; in comparison, no significant difference was found among WKHT, WKHA, and WKY. In contrast to the findings in coronary arteries, there was no significant difference in 5-HT-induced contractions in small mesenteric artery strips isolated from SHR and WKY. Conclusions: Coronary artery contractile reactivity to 5-HT does not correlate entirely with blood pressure (BP) values. In addition, G-protein-mediated Ca2+ sensitization of contraction was increased and contributed to the coronary artery contractile hyperreactivity in SHR.
AB - Background: Both coronary artery contractile hyperreactivity and hypertension are associated with increased coronary artery disease. It is not known how coronary artery contractile hyperreactivity relates to hypertension. The current study tests the hypothesis that coronary artery contractile hyperreactivity can be dissociated from hypertension and therefore may contribute to the etiology of CAD independent of hypertension. Methods: The contractile responses to 5-hydroxytryptamine (5-HT) and guanosine triphosphate (GTP) were determined in intact (nonpermeabilized) and α-toxin-permeabilized coronary artery strips and small mesenteric artery strips isolated from four rat strains: spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), WKY-derived hypertensive rats (WKHT), and WKY-derived hyperactive rats (WKHA). Results: The SHR and WKHT were hypertensive, whereas the WKY and WKHA subjects were normotensire. The coronary artery contractile reactivity to 5-HT was significantly higher in SHR when compared with WKY. The coronary artery contractile reactivity was of similar magnitude in WKHA and WKHT and was intermediate between that of SHR and WKY rats. GTP-induced Ca2+ sensitization of contractions were significantly greater in SHR than in WKHT, WKHA, and WKY; in comparison, no significant difference was found among WKHT, WKHA, and WKY. In contrast to the findings in coronary arteries, there was no significant difference in 5-HT-induced contractions in small mesenteric artery strips isolated from SHR and WKY. Conclusions: Coronary artery contractile reactivity to 5-HT does not correlate entirely with blood pressure (BP) values. In addition, G-protein-mediated Ca2+ sensitization of contraction was increased and contributed to the coronary artery contractile hyperreactivity in SHR.
KW - Ca sensitization of contraction
KW - Coronary artery hyperreactivity
KW - Coronary heart disease
KW - Hypertension
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U2 - 10.1016/S0895-7061(03)00862-8
DO - 10.1016/S0895-7061(03)00862-8
M3 - Article
C2 - 12850391
AN - SCOPUS:0038574579
SN - 0895-7061
VL - 16
SP - 570
EP - 576
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 7
ER -