Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin

Sunggu Yang; Gubbi Govindaiah; Sang Hun Lee; Sungchil Yang; Charles L. Cox

doi:10.1371/journal.pone.0189690

Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin

Sunggu Yang, Gubbi Govindaiah, Sang Hun Lee, Sungchil Yang, Charles L. Cox

Neuroscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABA_A receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABA_A receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABA_AR-mediated responses could be an important role in temporal coding of visual signals.

Original language	English
Article number	e0189690
Journal	PLoS ONE
Volume	12
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0189690
State	Published - Dec 2017

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2016R1D1A1B04930938), an Incheon National University (International Cooperative) Research Grant (SY), the National Institutes of Health grant EY014024 (CLC), the College of Medicine, University of Arkansas for Medical Sciences (startup funding to SHL), Bogard Neurology Research and Stroke Prevention Fund, and Core Facilities of the Center for Translational Neuroscience, Award P30 GM110702 from the IDeA program at NIGMS.

Publisher Copyright:
© This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)
General

Access to Document

10.1371/journal.pone.0189690

Cite this

@article{b5b6c874589a42409a39b2642eb7ca31,

title = "Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin",

abstract = "Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.",

author = "Sunggu Yang and Gubbi Govindaiah and Lee, {Sang Hun} and Sungchil Yang and Cox, {Charles L.}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2016R1D1A1B04930938), an Incheon National University (International Cooperative) Research Grant (SY), the National Institutes of Health grant EY014024 (CLC), the College of Medicine, University of Arkansas for Medical Sciences (startup funding to SHL), Bogard Neurology Research and Stroke Prevention Fund, and Core Facilities of the Center for Translational Neuroscience, Award P30 GM110702 from the IDeA program at NIGMS. Publisher Copyright: {\textcopyright} This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",

year = "2017",

month = dec,

doi = "10.1371/journal.pone.0189690",

language = "English",

volume = "12",

number = "12",

}

TY - JOUR

T1 - Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin

AU - Yang, Sunggu

AU - Govindaiah, Gubbi

AU - Lee, Sang Hun

AU - Yang, Sungchil

AU - Cox, Charles L.

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (2016R1D1A1B04930938), an Incheon National University (International Cooperative) Research Grant (SY), the National Institutes of Health grant EY014024 (CLC), the College of Medicine, University of Arkansas for Medical Sciences (startup funding to SHL), Bogard Neurology Research and Stroke Prevention Fund, and Core Facilities of the Center for Translational Neuroscience, Award P30 GM110702 from the IDeA program at NIGMS. Publisher Copyright: © This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

PY - 2017/12

Y1 - 2017/12

N2 - Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.

AB - Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN) transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN) neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals) and dendritic (F2 terminals) onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals) onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ) of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs) originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.

UR - http://www.scopus.com/inward/record.url?scp=85038937569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038937569&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0189690

DO - 10.1371/journal.pone.0189690

M3 - Article

C2 - 29252999

AN - SCOPUS:85038937569

VL - 12

IS - 12

M1 - e0189690

ER -

Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this