Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins

K. Babb, N. El-Hage, J. C. Miller, J. A. Carroll, B. Stevenson

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety of environmental stimuli, including soluble chemicals, which enables it to independently control synthesis of the Erp and OspC proteins. Regulation of OspC and Erp expression appears to occur at the level of transcription. In this regard, we observed that one or more DNA-binding proteins interact specifically with erp promoter DNA but not with the ospC promoter.

Original languageEnglish
Pages (from-to)4146-4153
Number of pages8
JournalInfection and Immunity
Volume69
Issue number6
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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