TY - JOUR
T1 - Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins
AU - Babb, K.
AU - El-Hage, N.
AU - Miller, J. C.
AU - Carroll, J. A.
AU - Stevenson, B.
PY - 2001
Y1 - 2001
N2 - Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety of environmental stimuli, including soluble chemicals, which enables it to independently control synthesis of the Erp and OspC proteins. Regulation of OspC and Erp expression appears to occur at the level of transcription. In this regard, we observed that one or more DNA-binding proteins interact specifically with erp promoter DNA but not with the ospC promoter.
AB - Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease-causing bacteria. We present results of studies indicating that B. burgdorferi senses a wide variety of environmental stimuli, including soluble chemicals, which enables it to independently control synthesis of the Erp and OspC proteins. Regulation of OspC and Erp expression appears to occur at the level of transcription. In this regard, we observed that one or more DNA-binding proteins interact specifically with erp promoter DNA but not with the ospC promoter.
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U2 - 10.1128/IAI.69.6.4146-4153.2001
DO - 10.1128/IAI.69.6.4146-4153.2001
M3 - Article
C2 - 11349090
AN - SCOPUS:0035010087
SN - 0019-9567
VL - 69
SP - 4146
EP - 4153
JO - Infection and Immunity
JF - Infection and Immunity
IS - 6
ER -