Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

Chen Guang Yu

doi:10.1007/s11515-012-1220-4

Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

Chen Guang Yu

Neuroscience

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Mitogen-activated protein kinases ERK1 and ERK2 have been implicated in various pathophysiological events of the CNS, but their specific roles in cell processes under physiologic and pathological conditions remain to be determined. ERK1/2 was originally identified as a kinase activity that mediates neuronal survival and neuroprotection, but it was subsequently found that ERK1/2 also plays a critical role in neurodegeneration. This dichotomy makes it difficult to target ERK1/2 for neuroprotection. Accumulating evidence suggests that ERK1 and ERK2 may play distinct functions in a variety of cell fate decisions. In this review, I summarize recent evidence for distinct roles for individual ERK isoforms in pathophysiology of the CNS.

Original language	English
Pages (from-to)	267-276
Number of pages	10
Journal	Frontiers in Biology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1007/s11515-012-1220-4
State	Published - Jun 2012

Bibliographical note

Funding Information:
The author would like to thank Dr. James Geddes for comments on the manuscript. This research was supported by grants from the Paralysis Project of America and the Kentucky Spinal Cord and Head Injury Research Trust (#7-6A and 11-19A).

Keywords

ERK isoform
cell death
cell proliferation
neurodegeneration
neuroprotection

ASJC Scopus subject areas

Biotechnology
Ecology, Evolution, Behavior and Systematics
Ecology
Genetics

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10.1007/s11515-012-1220-4

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title = "Distinct roles for ERK1 and ERK2 in pathophysiology of CNS",

abstract = "Mitogen-activated protein kinases ERK1 and ERK2 have been implicated in various pathophysiological events of the CNS, but their specific roles in cell processes under physiologic and pathological conditions remain to be determined. ERK1/2 was originally identified as a kinase activity that mediates neuronal survival and neuroprotection, but it was subsequently found that ERK1/2 also plays a critical role in neurodegeneration. This dichotomy makes it difficult to target ERK1/2 for neuroprotection. Accumulating evidence suggests that ERK1 and ERK2 may play distinct functions in a variety of cell fate decisions. In this review, I summarize recent evidence for distinct roles for individual ERK isoforms in pathophysiology of the CNS.",

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N1 - Funding Information: The author would like to thank Dr. James Geddes for comments on the manuscript. This research was supported by grants from the Paralysis Project of America and the Kentucky Spinal Cord and Head Injury Research Trust (#7-6A and 11-19A).

PY - 2012/6

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N2 - Mitogen-activated protein kinases ERK1 and ERK2 have been implicated in various pathophysiological events of the CNS, but their specific roles in cell processes under physiologic and pathological conditions remain to be determined. ERK1/2 was originally identified as a kinase activity that mediates neuronal survival and neuroprotection, but it was subsequently found that ERK1/2 also plays a critical role in neurodegeneration. This dichotomy makes it difficult to target ERK1/2 for neuroprotection. Accumulating evidence suggests that ERK1 and ERK2 may play distinct functions in a variety of cell fate decisions. In this review, I summarize recent evidence for distinct roles for individual ERK isoforms in pathophysiology of the CNS.

AB - Mitogen-activated protein kinases ERK1 and ERK2 have been implicated in various pathophysiological events of the CNS, but their specific roles in cell processes under physiologic and pathological conditions remain to be determined. ERK1/2 was originally identified as a kinase activity that mediates neuronal survival and neuroprotection, but it was subsequently found that ERK1/2 also plays a critical role in neurodegeneration. This dichotomy makes it difficult to target ERK1/2 for neuroprotection. Accumulating evidence suggests that ERK1 and ERK2 may play distinct functions in a variety of cell fate decisions. In this review, I summarize recent evidence for distinct roles for individual ERK isoforms in pathophysiology of the CNS.

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KW - cell death

KW - cell proliferation

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KW - neuroprotection

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JO - Frontiers in Biology

JF - Frontiers in Biology

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Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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