Diversifying vancomycin via chemoenzymatic strategies

Xun Fu; Christoph Albermann; Changsheng Zhang; Jon S. Thorson

doi:10.1021/ol0501626

Diversifying vancomycin via chemoenzymatic strategies

Xun Fu, Christoph Albermann, Changsheng Zhang, Jon S. Thorson

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

Original language	English
Pages (from-to)	1513-1515
Number of pages	3
Journal	Organic Letters
Volume	7
Issue number	8
DOIs	https://doi.org/10.1021/ol0501626
State	Published - Apr 14 2005

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0501626

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title = "Diversifying vancomycin via chemoenzymatic strategies",

abstract = "(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.",

author = "Xun Fu and Christoph Albermann and Changsheng Zhang and Thorson, {Jon S.}",

year = "2005",

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AU - Fu, Xun

AU - Albermann, Christoph

AU - Zhang, Changsheng

AU - Thorson, Jon S.

PY - 2005/4/14

Y1 - 2005/4/14

N2 - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

AB - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

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DO - 10.1021/ol0501626

M3 - Article

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JO - Organic Letters

JF - Organic Letters

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Diversifying vancomycin via chemoenzymatic strategies

Abstract

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