Diversifying vancomycin via chemoenzymatic strategies

Xun Fu; Christoph Albermann; Changsheng Zhang; Jon S. Thorson

doi:10.1021/ol0501626

Diversifying vancomycin via chemoenzymatic strategies

Xun Fu, Christoph Albermann, Changsheng Zhang, Jon S. Thorson

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

Original language	English
Pages (from-to)	1513-1515
Number of pages	3
Journal	Organic Letters
Volume	7
Issue number	8
DOIs	https://doi.org/10.1021/ol0501626
State	Published - Apr 14 2005

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	R01AI052218

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol0501626

Cite this

@article{cb55d58c43014b89b89aac5708920b9e,

title = "Diversifying vancomycin via chemoenzymatic strategies",

abstract = "(Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.",

author = "Xun Fu and Christoph Albermann and Changsheng Zhang and Thorson, \{Jon S.\}",

year = "2005",

month = apr,

day = "14",

doi = "10.1021/ol0501626",

language = "English",

volume = "7",

pages = "1513--1515",

number = "8",

}

TY - JOUR

T1 - Diversifying vancomycin via chemoenzymatic strategies

AU - Fu, Xun

AU - Albermann, Christoph

AU - Zhang, Changsheng

AU - Thorson, Jon S.

PY - 2005/4/14

Y1 - 2005/4/14

N2 - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

AB - (Chemical Equation Presented) The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.

UR - https://www.scopus.com/pages/publications/17844409813

UR - https://www.scopus.com/inward/citedby.url?scp=17844409813&partnerID=8YFLogxK

U2 - 10.1021/ol0501626

DO - 10.1021/ol0501626

M3 - Article

C2 - 15816740

AN - SCOPUS:17844409813

SN - 1523-7060

VL - 7

SP - 1513

EP - 1515

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Diversifying vancomycin via chemoenzymatic strategies

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this