Diverticulitis in HIV-infected patients within the United States

K. Cronley, J. Wenzke, H. Hussan, A. M. Vasquez, A. Hinton, S. El-Dika, D. L. Conwell, S. G. Krishna, P. P. Stanich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: Diverticulitis in patients on immunosuppressant therapy has been associated with increased mortality, but there are no data for HIV-infected patients. Our aim was to compare the outcomes of hospitalizations for diverticulitis in patients with and without HIV infection. Methods: Cross-sectional study of hospitalizations in the United States accessed through the Nationwide Inpatient Sample, Healthcare Cost and Utilization Project. Patients hospitalized for diverticulitis in 2007-2011 were included in the analysis. The primary outcomes of interest were mortality and surgical therapy rates. Patients from 2003 to 2011 were utilized to analyse trends in prevalence. Results: There were 2375 patients with HIV infection hospitalized for diverticulitis and 1 160 391 patients without HIV infection hospitalized for diverticulitis from 2007 to 2011. The patients with HIV infection were younger and more likely to be male and nonwhite (P < 0.001 for all). There were also differences in insurance types (P < 0.001) and hospitals [size (P = 0.008), type (P < 0.001) and location (P < 0.001)]. After multivariate analysis, patients with diverticulitis and HIV infection had a significantly increased in-hospital mortality rate [odds ratio (OR) 3.94 (95% confidence interval, CI, 1.52-10.20)] and a lower rate of surgical intervention [OR 0.74 (95% CI 0.57-0.95)]. From 2003 to 2011, there was a linear increasing trend in the prevalence of HIV infection among patients hospitalized for diverticulitis (P < 0.001). Conclusions: HIV-infected patients with diverticulitis had increased mortality and received less surgical treatment in comparison to the general population. Diverticulitis in HIV-infected patients increased in prevalence over the study period.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalHIV Medicine
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2016

Bibliographical note

Publisher Copyright:
© 2016 British HIV Association.

Keywords

  • AIDS
  • Colonic
  • Diverticulitis
  • Nationwide Inpatient Sample
  • United States

ASJC Scopus subject areas

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)

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