DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains

Renata L.A. Furlan, Stephen J. Watt, Leandro M. Garrido, Gustavo P. Amarante-Mendes, Mohammad Nur-E-Alam, Jurgen Rohr, Alfredo Braña, Carmen Mendez, Jose A. Salas, Margaret M. Sheil, Jennifer L. Beck, Gabriel Padilla

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex of daunorubicin with the same DNA sequence. This is the first study showing DNA binding properties of an anthracycline containing a β-rhodomycinone aglycone chromophore O-linked to two trisaccharide chains.

Original languageEnglish
Pages (from-to)647-654
Number of pages8
JournalJournal of Antibiotics
Issue number10
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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