Abstract
Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 16-29 |
| Number of pages | 14 |
| Journal | Cell Stem Cell |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 7 2011 |
Funding
We thank Drs. E. Pietras and M. Warr for their insightful comments. C.B. and P.A.S are chercheur qualifié of the Fonds de la Recherche Scientifique (F.R.S.)/Fonds National de la Recherche Scientifique (FNRS). M.M. is supported by a CIRM predoctoral training grant. This work was supported by the program CIBLES of the Wallonia Region, a research grant from the Fondation Contre le Cancer and the fond Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program to C.B., and a CIRM New Faculty Award and Rita Allen Scholar Award to E.P.
| Funders | Funder number |
|---|---|
| California Institute for Regenerative Medicine | |
| European Molecular Biology Organization | |
| H2020 European Research Council | |
| Stichting Tegen Kanker |
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology
