DNA repair and transcription

Prakash K. Bhatia, Zhigang Wang, Errol C. Friedberg

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume6
Issue number2
DOIs
StatePublished - Apr 1996

Bibliographical note

Funding Information:
PK Bhatia is a doctoral student in the Medical Scientist Training I)rogram at the University of'li:xas Southwestern Medical Center. Z Wang is supported by grant CA/O1)67978 from the United States Public Hcahh Service. EC Fricdberg is supported by grants CA12428 and CA44247 from the tlnited States Public Health Service.

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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