DNA repair and transcription

Prakash K. Bhatia; Zhigang Wang; Errol C. Friedberg

doi:10.1016/S0959-437X(96)80043-8

DNA repair and transcription

Prakash K. Bhatia, Zhigang Wang, Errol C. Friedberg

Toxicology and Cancer Biology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.

Original language	English
Pages (from-to)	146-150
Number of pages	5
Journal	Current Opinion in Genetics and Development
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/S0959-437X(96)80043-8
State	Published - Apr 1996

Bibliographical note

Funding Information:
PK Bhatia is a doctoral student in the Medical Scientist Training I)rogram at the University of'li:xas Southwestern Medical Center. Z Wang is supported by grant CA/O1)67978 from the United States Public Hcahh Service. EC Fricdberg is supported by grants CA12428 and CA44247 from the tlnited States Public Health Service.

ASJC Scopus subject areas

Genetics
Developmental Biology

Access to Document

10.1016/S0959-437X(96)80043-8

Cite this

@article{4de0ff7fac184140920b959fc1485578,

title = "DNA repair and transcription",

abstract = "The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.",

author = "Bhatia, {Prakash K.} and Zhigang Wang and Friedberg, {Errol C.}",

note = "Funding Information: PK Bhatia is a doctoral student in the Medical Scientist Training I)rogram at the University of'li:xas Southwestern Medical Center. Z Wang is supported by grant CA/O1)67978 from the United States Public Hcahh Service. EC Fricdberg is supported by grants CA12428 and CA44247 from the tlnited States Public Health Service.",

year = "1996",

month = apr,

doi = "10.1016/S0959-437X(96)80043-8",

language = "English",

volume = "6",

pages = "146--150",

number = "2",

}

TY - JOUR

T1 - DNA repair and transcription

AU - Bhatia, Prakash K.

AU - Wang, Zhigang

AU - Friedberg, Errol C.

N1 - Funding Information: PK Bhatia is a doctoral student in the Medical Scientist Training I)rogram at the University of'li:xas Southwestern Medical Center. Z Wang is supported by grant CA/O1)67978 from the United States Public Hcahh Service. EC Fricdberg is supported by grants CA12428 and CA44247 from the tlnited States Public Health Service.

PY - 1996/4

Y1 - 1996/4

N2 - The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.

AB - The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include, TFIIH.

UR - http://www.scopus.com/inward/record.url?scp=0030010367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030010367&partnerID=8YFLogxK

U2 - 10.1016/S0959-437X(96)80043-8

DO - 10.1016/S0959-437X(96)80043-8

M3 - Article

C2 - 8722169

AN - SCOPUS:0030010367

SN - 0959-437X

VL - 6

SP - 146

EP - 150

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 2

ER -

DNA repair and transcription

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this