Does mitotic rate predict sentinel lymph node metastasis or survival in patients with intermediate and thick melanoma?

Brent A. Roach, Alison L. Burton, Michael P. Mays, Brooke A. Ginter, Robert C.G. Martin, Arnold J. Stromberg, Lee Hagendoorn, Kelly M. McMasters, Charles R. Scoggins

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Background: The significance of mitotic rate (MR) in melanoma remains controversial. Methods In this retrospective analysis of a prospective randomized trial that included patients with melanoma of 1.0 mm or greater, all patients underwent wide excision and sentinel node (sentinel lymph node [SLN]) biopsy. Univariate and multivariate analyses were performed to evaluate factors predictive of disease-free survival (DFS) and overall survival (OS). Results A total of 551 patients had MR reported. A cut-off point of 6 mitoses/mm 2 best discriminated DFS and OS: 455 patients (82.6%) had MR less than 6/mm2. SLN were tumor-positive in 14.7% of low MR versus 31.3% of high MR patients (P = .0003). There were significant differences in DFS (P = .0014) and OS (P = .0002) between the 2 groups, however, MR failed to remain significant in the multivariate model. Conclusions MR is weakly predictive of SLN status but it is not an independent predictor of survival for melanomas 1.0 mm or thicker.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalAmerican Journal of Surgery
Volume200
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Melanoma
  • Mitotic rate
  • Sentinel lymph node
  • Survival

ASJC Scopus subject areas

  • Surgery

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