Dopamine depletion in nucleus accumbens reduces ACTH1-24-induced excessive grooming

Joe E. Springer; Robert L. Isaacson; Jeanne P. Ryan; John H. Hannigan

doi:10.1016/0024-3205(83)90378-8

Dopamine depletion in nucleus accumbens reduces ACTH_1-24-induced excessive grooming

Joe E. Springer, Robert L. Isaacson, Jeanne P. Ryan, John H. Hannigan

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH_1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Life Sciences
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(83)90378-8
State	Published - Jul 18 1983

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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abstract = "Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.",

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N2 - Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.

AB - Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.

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Dopamine depletion in nucleus accumbens reduces ACTH_1-24-induced excessive grooming

Abstract

ASJC Scopus subject areas

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