Dopamine depletion in nucleus accumbens reduces ACTH1-24-induced excessive grooming

Joe E. Springer, Robert L. Isaacson, Jeanne P. Ryan, John H. Hannigan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalLife Sciences
Issue number3
StatePublished - Jul 18 1983

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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