The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.
|Journal||Trends in Neurosciences|
|Issue number||10 SUPPL.|
|State||Published - 2000|
Bibliographical noteFunding Information:
The authors' research was supported by grants from the Medical Research Council of Canada (MRC; P.J.B. and T.D.P.) and the Parkinson Foundation of Canada (T.D.P. and P.J.B.). F.C. holds a health professional studentship from Novartis in association with the MRC of Canada and from the Fonds de la Recherche en Sant~ du Quebec.
ASJC Scopus subject areas
- Neuroscience (all)