Dopamine-receptor stimulation: Biobehavioral and biochemical consequences

Frédéric Calon, Abdallah Hadj Tahar, Pierre J. Blanchet, Marc Morissette, Richard Grondin, Martin Goulet, Jean Pierre Doucet, George S. Robertson, Eric Nestler, Thérèse Di Paolo, Paul J. Bédard

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

The MPTP monkey is a well-characterized animal model of parkinsonism and provides an exceptional tool for the study of dyskinesias induced by dopamine-like agents. Several such agents have been tested during the past 15 years, and it has been found that the duration of action of these compounds is the most reliable variable with which to predict their dyskinesiogenic profile. It is proposed that L-dopa-induced dyskinesias represent a form of pathological learning caused by chronic pulsatile (nonphysiological) stimulation of dopamine receptors, which activates a cascade of molecular and biochemical events. These events include defective regulation of Fos proteins that belong to the ΔFosB family, increased expression of neuropeptides, and defective GABA- and glutamate-mediated neurotransmission in the output structures of the basal ganglia.

Original languageEnglish
Pages (from-to)S92-S100
JournalTrends in Neurosciences
Volume23
Issue number10 SUPPL.
DOIs
StatePublished - 2000

Bibliographical note

Funding Information:
The authors' research was supported by grants from the Medical Research Council of Canada (MRC; P.J.B. and T.D.P.) and the Parkinson Foundation of Canada (T.D.P. and P.J.B.). F.C. holds a health professional studentship from Novartis in association with the MRC of Canada and from the Fonds de la Recherche en Sant~ du Quebec.

ASJC Scopus subject areas

  • General Neuroscience

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